| 丹红注射液对大鼠脑缺血再灌注损伤的保护作用 |
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| 引用本文： | 韩永鹏,安 芸. 丹红注射液对大鼠脑缺血再灌注损伤的保护作用[J]. 医学教育探索, 2010, 33(5): 388-390 |
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| 作者姓名： | 韩永鹏 安 芸 |
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| 作者单位： | 1 北京市中西医结合医院，北京 100039； 2 菏泽医学专科学校，山东 菏泽 274030 |
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| 摘 要： | 目的：研究丹红注射液对大鼠缺血再灌注损伤的保护作用。方法：采用线栓法建立大鼠脑缺血再灌注模型，观察丹红注射液对脑缺血再灌注损伤大鼠的神经功能评分、脑组织中一氧化氮合酶（NOS）、一氧化氮（NO）、超氧化物歧化酶（SOD）、丙二醛（MDA）等的影响。结果：丹红注射液可显著降低脑缺血再灌注大鼠的神经功能评分，减轻脑组织损伤程度；提高SOD活力，降低MDA和NO、NOS水平。结论：丹红注射液对大鼠缺血再灌注损伤具有明显的保护作用。
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| 关 键 词： | 丹红注射液；脑缺血再灌注损伤；大鼠；神经功能 |
| 收稿时间： | 2010-06-05 |
Protection of Danhong Injection on cerebral ischemia-reperfusion injury of rats |
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| HAN Yong-peng,AN Yun. Protection of Danhong Injection on cerebral ischemia-reperfusion injury of rats[J]. Researches in Medical Education, 2010, 33(5): 388-390 |
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| Authors: | HAN Yong-peng AN Yun |
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| Affiliation: | 1 Beijing Hospital of Integrated Traditional and Western Medicine, Beijing 100039, China; 2 Heze Medical College, Heze 274030, China |
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| Abstract: | Objective: To investigate the protection of Danhong Injection on the cerebral ischemia-reperfusion injury of rats. Methods: The models of focal brain ischemia-reperfusion injury were prepared by middle cerebral artery occlusion (MCAO) in rats. The effects of Danhong Injection on the cerebral ischemia-reperfusion injury of rats, such as nerve function grade and contents of NOS, NO, SOD, and MDA in brain tissues, were observed. Results: Danhong Injection could decrease the nerve function grade, improve the vigor of SOD, depress the levels of MDA, NO, and NOS. Conclusion: Danhong Injection can protect the brain from ischemia-reperfusion injury in rats. |
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| Keywords: | Danhong Injection cerebral ischemia-reperfusion injury rat nerve function |
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