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| 抑癌基因p33/ING1与食管鳞癌 | |
| 引用本文： | 李慧娥,冷雪芹,宋光明. 抑癌基因p33/ING1与食管鳞癌[J]. 内蒙古医学杂志, 2011, 43(5): 524-527,F0004 |
| 作者姓名： | 李慧娥 冷雪芹 宋光明 |
| 作者单位： | 1. 呼和浩特市第一医院消化内科,内蒙古呼和浩特,010030 2. 内蒙古医学院附属医院消化内科,内蒙古呼和浩特,010050 3. 内蒙古农业大学职业技术学院医院,内蒙古呼和浩特,010010 |
| 摘 要： | 目的：探讨食管癌的发生、发展、浸润及转移过程中p33/ING1蛋白的表达及其与食管癌病理特征的关系,以寻求预防、诊断和治疗食管癌的新方法。方法：选择手术切除食管癌手术后大体标本58例,采用免疫组织化学技术检测凋亡促进因子P33/ING1在58例食管癌大体标本中的食管鳞癌组织、癌旁不典型增生组织及其相应的正常食管黏膜组织中的表达。结果：p33/ING1蛋白从正常黏膜-不典型增生-浸润癌渐进性表达减低。结论：p33/ING1的阳性表达率随着分化程度的降低而降低,随着浸润深度的增加而降低,随着淋巴结的转移而降低,提示p33/ING1基因的失活（或缺失）及蛋白表达的下降在食管鳞癌的发生、分化及浸润转移过程中起重要作用。p33/ING1在食管鳞癌组织表达的下降或缺损,提示食管鳞癌可能发生了浸润甚至淋巴结转移,预后不良。 |
| 关 键 词： | 食管癌 p33/ING1 抑癌基因 免疫组织化学 |
Tumor Suppressor Gene p33/ING1 and Esophageal Squamous Carcinoma |
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| LI Hui-e,LENG Xue-qin,SONG Guang-ming. Tumor Suppressor Gene p33/ING1 and Esophageal Squamous Carcinoma[J]. Inner Mongolia Medical Journal, 2011, 43(5): 524-527,F0004 | |
| Authors: | LI Hui-e LENG Xue-qin SONG Guang-ming |
| Affiliation: | LI Hui-e1,LENG Xue-qin2,SONG Guang-ming3(1.Department of Gastroenterology,The First Hospital in Hohhot,Huhhot 010030 China,2.Department of Gastroenterology,The Affiliated Hospital of Inner Medical College Huhhot 010050 China,3.The Hospital of Uocational and Technical College of Inner Mongolia Agricultural University,Huhhot 010010 China) |
| Abstract: | Objective:To explore the expression of p33/ING1 and its relationship with the pathological features of esophageal carcinoma in the esophageal cancer occurrence,development,infiltration and transfer process.Methods:We obtained 58 esophageal carcinoma general tissue specimens from 58 patients who received esophageal resection.The apoptosis-promoting factor P33/ING1 in the esophageal squamous carcinoma tissues,atypical hyperplasia tissues and normal esophageal tissues was detected by immunohistochemistry.Resul... |
| Keywords: | Esophageal cancer p33/ING1 Tumor suppressor gene Immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |