| 头孢氨苄胶囊溶出度测定方法的改进 |
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| 引用本文： | 霍天凤,秦松,李娜. 头孢氨苄胶囊溶出度测定方法的改进[J]. 中国医药导报, 2010, 7(22): 74-75 |
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| 作者姓名： | 霍天凤 秦松 李娜 |
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| 作者单位： | 河南省焦作市食品药品检验所,河南焦作,454000 |
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| 摘 要： | 目的：改进头孢氨苄胶囊溶出度的测定方法。方法：采用高效液相色谱法测定,对改进方法的精密度、线性关系、回收率进行了考察,同时将改进方法的测定结果与《中国药典》方法进行了比较。结果：头孢氨苄在12.5～250.0μg/ml浓度范围内,峰面积与浓度呈良好的线性关系（r=1.0000）,回收率为99.5%,RSD=0.63%（n=6）。结论：改进后的方法更准确、精密、科学,比《中国药典》方法测得结果更满意。
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| 关 键 词： | 头孢氨苄胶囊 溶出度 高效液相色谱法 紫外分光光度法 |
Improvement of the dissolution determining method of Cefalexin Capsules |
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| HUO Tianfeng,QIN Song,LI Na. Improvement of the dissolution determining method of Cefalexin Capsules[J]. China Medical Herald, 2010, 7(22): 74-75 |
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| Authors: | HUO Tianfeng QIN Song LI Na |
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| Affiliation: | (Jiaozuo Institute for Food and Drug Control,Jiaozuo 454000,China) |
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| Abstract: | Objective：To improvement the determining method of dissolution of Cefalexin Capsules.Methods：Dissonlution of Cefalexin was determined by HPLC.The accuracy,precision,linearity and recovery of the improved method were investigated.Then,we compared the results obtained from this improved method and the China Pharmacopoeia method.Results：The linear ranges of cefalexin was at 12.5-250.0（r=1.000 0）,and the average recovery was 99.5% with a RSD of 0.63%（n=6）.Conclusion：The improved method is more accurate,precise,scientific.The results is more satisfactory than the results of the China Pharmacopoeia method. |
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| Keywords: | Cefalexin Capsules Dissolution HPLC UV |
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