纳洛酮治疗慢性阻塞性肺疾病所致肺性脑病的疗效及安全性评价

目的 观察评价纳洛酮治疗慢性阻塞性肺疾病(COPD)所致肺性脑病临床疗效及安全性.方法 将入选70例病例随机分为治疗组及对照组,两组均予以积极控制感染,持续低流量吸氧(给氧浓度为30%～40%,氧流量为1～3 L/min,鼻导管给氧法),解痉平喘,保持气道通畅,维持酸碱、水、电解质平衡,营养支持等综合治疗.治疗组在此基础上加用纳洛酮注射剂(0.4 mg/支),首剂负荷量0.8 mg加入生理盐水20 ml中静脉推注,以后给予纳洛酮注射剂4 mg加入生理盐水500 ml中,用微量泵24 h持续静脉泵入,连用7 d.结果 治疗后,治疗组总有效率显著高于对照组(P＜0.05);治疗过程中无不良反应发生.结论 纳洛酮治疗COPD所致肺性脑病临床疗效确切、安全.

Clinical effect and safety of naloxone in the treatment of COPD with pulmonary encephalopathy

Objective To observe the clinical effect and safety of naloxone in treatment of COPD with pulmonary encephalopathy.Methods 70 patients with COPD with pulmonary encephalopathy were randomly divided into 2 groups,30 cases in the control group were received basic therapy includinganti-infection,relieving airway spasm and asthma,etc.40 cases in the treating group were given naloxone injection 4 mg intravenously by microsyringe for 7 days.Results After treatment,the overall effective rate in the treating group was significantly higher than that in the control group (P<0.05).Conclusion Naloxone is an effective and less side-effect medicine for treatment of COPD with pulmonary encephalopathy.