外用中药"癌症镇痛散"的镇痛作用研究

目的 通过动物实验进一步证实外用中药“癌症镇痛散”的镇痛药效。方法 利用小鼠醋酸扭体实验和大鼠NaCl扭体实验，以扭体抑制情况来验证疗效。结果 “癌症镇痛散”药膏腹部外敷对小鼠腹腔注射冰醋酸扭体有抑制作用，对大鼠腹腔注射NaCl所致扭体也有抑制作用，而且表现出明显的量效关系，高、中两个剂量组与空白对照组比较差异有显性。结论 “癌症镇痛散”外敷对动物腹腔内部疼痛有明显的治疗作用。

Study on Analgesic Effect of Chinese Traditional Medicine AI Zheng Zhen Tong San

Objective To further confirm the analgesic effect of external applied Chinese traditional medicine Ai Zheng Zhen Tong San in animal experiments. Methods Glacial acetic acid test in mice and NaCl test in rats were used to make the body twisting then to evaluate the efficacy of the drug. Results When external applied on the belly, Ai Zheng Zhen Tong San restrained the body twisting effect in mice induced by injecting 0.6% glacial acetic acid into abdominal cavity. And it also restrained the body twisting effect induced by injecting 4% NaCl into abdominal cavity in rats. The drug showed good correlation between doses and efficacy. It presented apparent analgesic effects under high and middle doses, while not under low dose. Conclusion Ai Zheng Zhen Tong San is effective when externally applied on the belly for inner ache of the abdominal cavity.