| 癌基因c—erbB2在膀胱移行细胞癌中的扩增与过表达 |
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| 引用本文： | 邵渊 张元芳. 癌基因c—erbB2在膀胱移行细胞癌中的扩增与过表达[J]. 中华泌尿外科杂志, 1997, 18(7): 401-403 |
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| 作者姓名： | 邵渊 张元芳 |
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| 作者单位： | 上海医科大学中山医院病理科，上海医科大学肝癌研究所 |
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| 摘 要： | 应用原位杂交和免疫组化对９３例膀胱移行细胞癌中癌基因ｃｅｒｂＢ２进行研究。８例（８６％）显示ｃｅｒｂＢ２的基因扩增，扩增与肿瘤病理分级呈正相关（Ｐ＜００５）。２４例（２５８％）显示ｃｅｒｂＢ２的蛋白过表达，过表达与肿瘤病理分级（Ｐ＜００１）、临床分期（Ｐ＜００５）及复发（Ｐ＜００５）均呈正相关。提示在膀胱移行细胞癌中，ｃｅｒｂＢ２的过表达比扩增具有更重要的临床意义。
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| 关 键 词： | 膀胱肿瘤 癌 基因 |
Amplification and overexpression of c erbB 2 in transitional cell carcinoma of urinary bladder |
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| Shao Yuan,Zhang Yuanfang,Pan Wensheng,et al.. Amplification and overexpression of c erbB 2 in transitional cell carcinoma of urinary bladder[J]. Chinese Journal of Urology, 1997, 18(7): 401-403 |
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| Authors: | Shao Yuan Zhang Yuanfang Pan Wensheng et al. |
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| Affiliation: | Shao Yuan,Zhang Yuanfang,Pan Wensheng,et al.Zhongshan Hospital,Shanghai Medical University,Shanghai 200032 |
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| Abstract: | Transitional cell bladder carcinoma spe cimens from 93 patients were studied by in situ hybridization and immunohistochemistry for c erbB 2 amplification and overexpression.8 of the 93 (8.6%) spe cimens were found to have amplificated c erbB 2 gene which was related to the tumor grade ( P <0 05).24(25.8%) specimens were found to have overexpression of the c erbB 2 which was also associated with the tumor grade ( P <0 01),the tumor stage ( P <0 05) and the recurrence rate ( P <0 05).The overexpression of c erbB 2 might provide more clues than the amplification of the gene in the evaluation of transitional cell carcinoma of the urinary bladder. |
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| Keywords: | Bladder neoplasms Carcinoma Gene |
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