| 缺血再灌流肾组织内皮素—1动态变化的实验研究 |
| |
| 引用本文： | 吴雄飞 金锡御. 缺血再灌流肾组织内皮素—1动态变化的实验研究[J]. 中华泌尿外科杂志, 1997, 18(7): 404-407 |
| |
| 作者姓名： | 吴雄飞 金锡御 |
| |
| 作者单位： | 第三军医大学西南医院泌尿外科 |
| |
| 摘 要： | 在大鼠肾缺血６０分钟再灌注的模型上观察不同时相肾静脉血、肾皮质、外髓和内髓的内皮素１（ＥＴ１）浓度变化，肾组织ＥＴ１光镜和电镜免疫组织化学变化。结果发现：缺血再灌流肾组织ＥＴ１基因表达及分泌明显增强，主要分布在血管内皮细胞及平滑肌细胞、系膜细胞、肾小管上皮细胞。其分布特点与细胞类型和活性有关。本实验结果提示了缺血再灌注肾内ＥＴ１的变化规律。
|
| 关 键 词： | 肾 局部缺血 灌注法 内皮素-1 |
An experimental study of the endothelin 1 change in rat kidney following ischemia reperfusion injury |
| |
| Wu Xiongfei,Jin Xiyu,Liu Hong,et al.. An experimental study of the endothelin 1 change in rat kidney following ischemia reperfusion injury[J]. Chinese Journal of Urology, 1997, 18(7): 404-407 |
| |
| Authors: | Wu Xiongfei Jin Xiyu Liu Hong et al. |
| |
| Affiliation: | Wu Xiongfei,Jin Xiyu,Liu Hong,et al.Department of Urology,The First Affiliated Hospital,The Third Mi litary Medical University,Chongqing 630038 |
| |
| Abstract: | The level of endothelin 1(ET 1) in renal vein plasma and kidney tissue (cortex,outer medulla and inter medulla respectively),immunocytochemical distribution of ET 1 in kidney tissue by light and electron microscopy,mRNA expression or localization of ET 1 in kidney by northern blot hybridization and in situ hybridization on rat model of renal ischemia reperfusion were investigated.Results showed that secretion and mRNA expression of ET 1 evidently increased and distributed primarily on endothelial cells,smooth muscle cells,glomerular mesangial cells and tubular epithelial cells.The distributions of ET 1 or ET 1 mRNA were closely related to the type and function of renal cells.The study revealed the changed pattern of ET 1 in kidney following ischemia reperfusion injury. |
| |
| Keywords: | Kidney Ischemia Perfusion Endothelin 1 |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
