| 抗癌药物诱导人膀胱癌BIU—87和E—J细胞凋亡的作用 |
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| 引用本文： | 赵长林,刘佳.抗癌药物诱导人膀胱癌BIU—87和E—J细胞凋亡的作用[J].中华泌尿外科杂志,1997,18(5):286-288. |
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| 作者姓名： | 赵长林 刘佳 |
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| 作者单位： | 沈阳医学院附属中心医院泌尿外科，沈阳医学院分子生物学研究室 |
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| 摘 要： | 应用分子生物学方法，观察了丝裂霉素、喜树碱、顺铂和阿霉素对膀胱癌细胞系ＢＩＵ８７和ＥＪ体外生长和生存的影响，对抗癌药物诱导膀胱癌细胞凋亡作用进行了研究。结果：四种抗癌药均能在不同程度上抑制膀胱癌细胞生长，诱导膀胱癌细胞凋亡的能力与其生长抑制效应成正比。细胞形态学和ＤＮＡ分析显示喜树碱、顺铂处理的ＢＩＵ８７和丝裂霉素、阿霉素处理的ＥＪ细胞呈现典型的凋亡现象。揭示药物的抑癌作用是通过诱导肿瘤细胞凋亡实现的，它可能是抑制肿瘤生长的机理之一。不同膀胱癌细胞系对药物诱导凋亡的敏感性存在着差异。细胞凋亡现象为肿瘤化疗提供了新的领域。
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| 关 键 词： | 膀胱肿瘤 癌 化疗 凋亡 |
Chemotherapy and apoptosis of BIU and E J bladder cancer cells |
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| Zhao Changlin,Liu Jia,Li Hong,et al..Chemotherapy and apoptosis of BIU and E J bladder cancer cells[J].Chinese Journal of Urology,1997,18(5):286-288. |
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| Authors: | Zhao Changlin Liu Jia Li Hong |
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| Institution: | Zhao Changlin,Liu Jia,Li Hong,et al.Department of Urology,the Central Hospital Affiliated to Shenyang Medical College,Shenyang,110024 |
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| Abstract: | The effect of some chemotherapeutic agents on the cell growth of BIU and E J bladder cancer cell lines was investigated. The in vitro cell growth inhibition and the hallmarks of apoptosis of BIU cells treated with 10 hydroxycamptothecini and cisplatin and E J cells treated with mytomycin c and adriamycin were studied. Apoptosis of the cancer cells was directly related to the growth suppression by these agents. It was suggested that the death of BIU and E J cancer cells induced by these chemotherapeutic drugs was through the apoptosis pathway. Different cancer cells responded differently to the anticancer drugs. The induction of apoptosis might be a new field in the study of anticancer chemotherapy. |
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| Keywords: | Bladder neoplasm Carcinoma Chemotherapy Apoptosis |
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