| ADYNAMIC STUDY OF THE CYTOTOXICEFFECTS OF HYPERTHERMIA COMBINED WITH CIS－DIAMINE DICHLOROLPLATINUM（DDP） ON HUMAN GASTRIC CANC |
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| 引用本文： | 陈卫星,厉有名,陈良良,季峰,黄怀德,刘祥麟. ADYNAMIC STUDY OF THE CYTOTOXICEFFECTS OF HYPERTHERMIA COMBINED WITH CIS－DIAMINE DICHLOROLPLATINUM（DDP） ON HUMAN GASTRIC CANC[J]. 中国癌症研究, 1996, 8(4): 298-300. DOI: 10.1007/BF02954755 |
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| 作者姓名： | 陈卫星 厉有名 陈良良 季峰 黄怀德 刘祥麟 |
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| 作者单位： | Chen Weixing;Li Youming;Chen Liangliang; Ji Feng;Huang Huaide; Liu Xianglin (Department of Gastroenterology，First Affiliated hospital，Zhejiang Medical University，HangZhou 310003)(Department of Oncology，Chinese Traditional Medical hospital of Zhejiang) |
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| 摘 要： | ＡＤＹＮＡＭＩＣＳＴＵＤＹＯＦＴＨＥＣＹＴＯＴＯＸＩＣＥＦＦＥＣＴＳＯＦＨＹＰＥＲＴＨＥＲＭＩＡＣＯＭＢＩＮＥＤＷＩＴＨＣＩＳ－ＤＩＡＭＩＮＥＤＩＣＨＬＯＲＯＬＰＬＡＴＩＮＵＭ（ＤＤＰ）ＯＮＨＵＭＡＮＧＡＳＴＲＩＣＣＡＮＣＥＲＣＥＬＬＬＩＮＥＳＭＫＮ...
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A dynamic study of the cytotoxic effects of hyperthermia combined with cis-diamine dichlorolplatinum (DDP) on human gastric cancer cell lines MKN28 and MKN45 in vitro |
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| Weixing Chen,Youming Li,Liangliang Chen,Feng Ji,Huaide Huang,Xianglin Liu. A dynamic study of the cytotoxic effects of hyperthermia combined with cis-diamine dichlorolplatinum (DDP) on human gastric cancer cell lines MKN28 and MKN45 in vitro[J]. Chinese Journal of Cancer Research, 1996, 8(4): 298-300. DOI: 10.1007/BF02954755 |
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| Authors: | Weixing Chen Youming Li Liangliang Chen Feng Ji Huaide Huang Xianglin Liu |
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| Affiliation: | 1. Department of Gastroenterology, First Affiliated hospital, Zhejiang Medical University, 310003, Hangzhou
2. Department of Oncology, Chinese Traditional Medical hospital of Zhejiang, China
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| Abstract: | Cytotoxic effects of hyperthermia combined with DDP on MKN28 and MKN45 cells were studied by MTT assay according to a nested design. The results showed: hyperthermia alone above 43 °C for 30 mins was cytotoxic; hyperthermia at temperature lower than 43 °C for 30 mins could increase sensitivity of cancer cells to DDP. The cytotoxic effect of simultaneous use of hyperthermia and DDP was more marked than that of sequential use of the 2 treatments. Hyperthermia combined with DDP could inhibit growth of human gastric adenocarcinoma cells regardless of their degree of differentiation. |
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| Keywords: | Gastric neoplasms Cisplatin Hyperthermia Induced |
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