Pharmacoeconomic evaluation of acute exacerbations of chronic bronchitis and COPD |
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Authors: | Miravitlles Marc,Murio Cristina,Guerrero Tina,Gisbert Ramon DAFNE Study Group. Decisiones sobre Antibioticoterapia y Farmacoeconomía en la EPOC |
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Affiliation: | Center Servei de Pneumologia, Hospital General Universitari Vall d'Hebron, Barcelona. marcm@separ.es |
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Abstract: | BACKGROUND: Although exacerbations are the main cause of medical visits and hospitalizations of patients with chronic bronchitis and COPD, little information is available on the costs of their management. OBJECTIVE: This study attempted to determine the total direct costs derived from the management of exacerbations of chronic bronchitis and COPD in an ambulatory setting. METHOD: A total of 2,414 patients with exacerbated chronic bronchitis and COPD were recruited from 268 general practices located throughout Spain. Patients were followed up for 1 month. RESULTS: A total of 507 patients (21%) relapsed; of these, 161 patients (31.7%) required attention in emergency departments and 84 patients (16.5%) were admitted to the hospital. The total direct mean cost of all exacerbations was $159; patients who were hospitalized generated 58% of the total cost. Cost per failure was $477.50, and failures were responsible for an added mean cost of $100.30/exacerbation. Exacerbations of the 1,130 patients with COPD had a mean cost of $141. Sensitivity analysis showed that a 50% reduction in the failure rate (from 21 to 10.5%) would result in a total cost of exacerbation of $107 (33% reduction). CONCLUSION: Exacerbations of chronic bronchitis and COPD are costly, but the greatest part of costs derives from therapeutic failures, particularly those that end in hospitalization. |
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Keywords: | chronic bronchitis COPD cost exacerbation failure pharmacoeconomics primary care treatment AECB" },{" #name" :" keyword" ," $" :{" id" :" cekeyw100" }," $$" :[{" #name" :" text" ," _" :" acute exacerbations of chronic bronchitis GP" },{" #name" :" keyword" ," $" :{" id" :" cekeyw120" }," $$" :[{" #name" :" text" ," _" :" general practitioner PFT" },{" #name" :" keyword" ," $" :{" id" :" cekeyw140" }," $$" :[{" #name" :" text" ," _" :" pulmonary function test |
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