鲜萝卜汁对动脉粥样硬化大鼠炎症因子的影响

目的：检测和分析鲜萝卜汁对动脉粥样硬化大鼠炎症因子的影响和意义。方法：100只成年Wistar雄鼠随机分为5组，每组20只，正常对照组，动脉粥样硬化模型组，鲜萝卜汁高剂量组，鲜萝卜汁低剂量组，阳性药组。除正常对照组，建模后。各组连续给药10周，检测血脂四项：血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白（LDL-C）、超氧化物歧化酶（SOD）和丙二醛（MDA）、白细胞介素-6（IL-6）和C-反应蛋白（CRP）水平。结果：经10周连续给药。萝卜汁高、低剂量组和血脂康胶囊组可显著降低动脉粥样硬化大鼠的TC、TG、LDL—C和HDL-C以及降低IL-6表达、血清CRP和MDA水平，升高SOD（P〈0．05）。结论：鲜萝卜汁通过降低动脉粥样硬化大鼠炎症因子，可达到治疗动脉粥样硬化的目的。

Study the Effect of Fresh Carrot Juice on Inflammatory Factors in Atherosclerotic Rats

Objective ：To detect and analyze the effect of fresh carrot juice on inflammatory factors of atherosclerotic rats. Methods： 100 Wistar male rats were randomly divided into five groups： 15 in normal control group, 20 in atherosclerotic model group, 20 in high- dose fresh carrot juice group, 20 in low-dose fresh carrot juice group, and 20 in positive medicine group. All the groups were admin- istered the corresponding medicines for 3 days before modeling. After modeling , all the groups were given medicines for 10 days. Serum total cholesterol （TC）, triglyceride （TG）, high density lipoprotein cholesterol （HDL-C）, Low -density lipoprotein （LDL-C）and superoxide dismutase （SOD）, malondialdehyde （MDA）, interleukin - 6 （IL-6）and C-reactive protein （ CRP ）were collected. Results： After 10 weeks continuous administration, high-and low-dose carrot juice groups and Xuezhikang group can significantly reduce atherosclerosis rats＇ TC, TG, LDL-C,HDL-C, IL - 6, CRP and MDA levels, increase SOD （P〈0.05）. Conclusion： Fresh carrot juice can treat atherosclerosis by reduce inflammatory factors.