118例溃疡性结肠炎临床、内镜与直肠动力分析

目的了解溃疡性结肠炎(UC)的临床、内镜和直肠动力特点。方法分析1982年2002年我院确诊118倒UC的临床、内镜、直肠动力特点。结果①UC症状以腹泻、粘液、粘液血便、腹痛为主,肠外表现少见;病程通常较短;病变范围以左半结肠为主;IgG、IgM升高;②肠镜下充血水肿最多见,其次是糜烂、溃疡;③腹压增加时肛门内外括约肌净增压降低(P<0.05),直肠最低敏感量、最大耐受性、最大顺应性明显降低(P<0.01);④大多数患者以柳氮磺胺吡啶治疗有效。结论了解UC的临床、内镜和直肠动力特点,有助于理解UC的发病规律、病理生理和更有效地治疗该病。

Analysis of clinical, endoscopic and anorectal motility features in 118 patients with ulcerative colitis

Aim To explore the clinical, endoscopic and anorectal motility characteristics of ulcerative colitis(UC). Methods The clinical, endoscopic and anorectal motility of 118 patients with UC diagnosed in our hospital from 1982 to 2002 were analyzed. Results 1. The most common clinical features were diarrhea, bloody mucopurutent stool and abdominal pain. The course was shorter, with rare extraintestinal manifestation. Lesions were commonly located in left side of the colon. The level of IgG and IgM was increased. 2. The characteristics of UC in colonoscopy were hyperemia edema, erosion and ulcer. 3. When abdominal pressure was increased, the net increased pressure of internal and external anal sphincter in UC was lower than those in healthy subjects (HS) (P<0.05). The rectal lowest volume of sensory threshold, the maximal volume of tolerance and maximal compliance in UC were also lower than those of HS (P<0.01). 4. The treatment was effective by taking SASP in UC. Conclusions It is beneficial for us to understand the clinical, endoscopic and anorectal motility features in UC.