| Abstract: | To study the possible role of glutathion (GSH) in cadmium-induced anti-tumor effects on human nasopharyngeal carcinoma(NPC).CNE1 cell line was treated with CdCl2,and together with N-acetyl cysteine(NAC),the predecessor of GSH,or with L-buthionine-[S,R]-sulfoximine (BSO),a selective inhibitor of GSH synthesis.The intracellular GSH level,the LDH leakage and MTT assay were measured.Results showed that there was remarkable proliferation in NAC CdCl2 treated CNE1 cells,with high activity of GSH.However,in BSO CdCl2 exposed cells,with low level GSH,the proliferation was significantly inhibited.It was indicated that GSH depletion would sensitize the inducible cytotoxicity in NPC cell,which correlated with cadmium-induced anticancer effects. |
