Early effects of cis-dichlorodiammine platinum (II) on tumor progression and programmed death of Ehrlich ascites carcinoma cells |
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| Authors: | Razin B V Inzhevatkin E V Nefedova V V Egorova A B Kazbanov V I Nefedov V P |
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| Institution: | (1) International Research Center for Extreme Body States, Presidium of the Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences, Russia;(2) Institute of Chemistry and Chemical Technology, Siberian Division of the Russian Academy of Sciences, Krasnoyarsk |
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| Abstract: | We studied the effects of cis-dichlorodiammine platinum (II) on different pathways of cell death in cultured Ehrlich ascites carcinoma in vitro and on subsequent growth of transplanted tumor in vivo. One-hour incubation with the cytostatic modulated apoptosis in cell culture. However, exposure of cell culture to a minimal effective concentration of cis-platinum(II)diammine dichloride promoted the growth of transplanted tumor. |
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| Keywords: | Ehrlich ascites carcinoma cis-dichlorodiammine platinum (II) apoptosis necrosis |
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