Pyrogenicity and cytokine-inducing properties of Streptococcus pyogenes superantigens: comparative study of streptococcal mitogenic exotoxin Z and pyrogenic exotoxin A |
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Authors: | Müller-Alouf H Proft T Zollner T M Gerlach D Champagne E Desreumaux P Fitting C Geoffroy-Fauvet C Alouf J E Cavaillon J M |
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Affiliation: | Département de Microbiologie des Ecosystèmes, Institut Pasteur de Lille, France. |
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Abstract: | Streptococcal mitogenic exotoxin Z (SMEZ), a superantigen derived from Streptococcus pyogenes, provoked expansion of human lymphocytes expressing the Vbeta 2, 4, 7 and 8 motifs of T-cell receptor. SMEZ was pyrogenic in rabbits and stimulated the expression of the T-cell activation markers CD69 and cutaneous lymphocyte-associated antigen. A variety of cytokines was released by human mononuclear leukocytes stimulated with SMEZ, which was 10-fold more active than streptococcal pyrogenic exotoxin A. Th2-derived cytokines were elicited only by superantigens and not by streptococcal cells. |
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