| 黄连合用肉桂多次灌胃对小檗碱在大鼠体内分布的影响 |
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| 引用本文： | 张瑞,李凯鹏,杨洁,黄果,杨丽娟,张玉杰.黄连合用肉桂多次灌胃对小檗碱在大鼠体内分布的影响[J].中国中药杂志,2010,35(16):2180-2183. |
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| 作者姓名： | 张瑞 李凯鹏 杨洁 黄果 杨丽娟 张玉杰 |
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| 作者单位： | 1. 北京中医药大学,中药学院,北京,100102
2. 中日友好医院,药剂科,北京,100029 |
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| 基金项目： | 国家自然科学基金项目(30672585) |
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| 摘 要： | 目的:探讨黄连合用肉桂多次灌胃给予大鼠对小檗碱体内分布的影响。方法:将大鼠随机分为3组,一组作为空白,一组灌服黄连药材粉末,另一组灌服黄连与肉桂按6∶1混合的药材粉末,连续灌胃7次。采用HPLC测定给药后大鼠心、肝、脾、肺、肾等脏器中小檗碱的浓度。采用SAS统计软件进行t检验,比较黄连配伍肉桂前后各脏器中小檗碱的变化情况。结果:大鼠多次灌胃黄连后,小檗碱组织浓度升高,其在大鼠体内呈广泛分布,但主要集中在肝组织中;黄连配伍肉桂后各脏器中小檗碱浓度发生明显的改变(P0.01),心、肝、肾中小檗碱浓度较之配伍前明显增加,而脾、肺中小檗碱浓度较配伍前明显减少。结论:黄连配伍肉桂后多次灌胃可使小檗碱在大鼠体内各脏器的分布发生明显的改变。
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| 关 键 词： | 黄连 肉桂 多次灌胃 小檗碱 组织分布 |
| 收稿时间： | 2009/9/23 0:00:00 |
Effect of Rhizoma Coptidis coadministration with Cortex Cinnamomi on tissue distribution of berberine in rats |
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| ZHANG Rui,LI Kaipeng,YANG Jie,HUANG Guo,YANG Lijuan and ZHANG Yujie.Effect of Rhizoma Coptidis coadministration with Cortex Cinnamomi on tissue distribution of berberine in rats[J].China Journal of Chinese Materia Medica,2010,35(16):2180-2183. |
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| Authors: | ZHANG Rui LI Kaipeng YANG Jie HUANG Guo YANG Lijuan and ZHANG Yujie |
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| Institution: | SchooL of Chinese Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102, China;Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, China;SchooL of Chinese Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102, China;SchooL of Chinese Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102, China;SchooL of Chinese Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102, China;SchooL of Chinese Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102, China |
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| Abstract: | |
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| Keywords: | Rhizoma Coptidis Cortex Cinnamomi coadministration berberine tissue distribution |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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