Protein synthesis in cells infected by murine hepatitis viruses JHM and A59: Tryptic peptide analysis |
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| Authors: | C W Bond K Anderson J L Leibowitz |
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| Institution: | (1) Department of Microbiology, Montana State University, Bozeman, Montana, USA;(2) Department of Pathology University of California, San Diego La Jolla, California, USA;(3) Department of Microbiology, Montana State University, 59717 Bozeman, MT, USA |
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| Abstract: | Summary The structural and intracellular proteins of the murine hepatitis viruses MHV-JHM and MHV-A59 were studied by tryptic peptide mapping. The results demonstrated that the virions contained three distinct proteins: the two related chains of the E2 complex, the nucleocapsid protein and the heterogeneous E1 complex. Five distinct virus-specific proteins were synthesized by infected cells. Three of the five intracellular proteins contained tryptic-peptides with properties similar to the three structural proteins. Models describing the evolution of the proteins are proposed. Although the pathogenic properties of MHV-JHM and MHV-A59 differ greatly, the tryptic peptide maps of the corresponding proteins of these MHV strains were remarkably similar.With 8 Figures |
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