| 舌体高分化鳞状细胞癌角蛋白谱的分析 |
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| 引用本文： | 席庆,周育森,陈万荣,潘英,丁美,于虹,步荣发.舌体高分化鳞状细胞癌角蛋白谱的分析[J].中华老年口腔医学杂志,2007,5(3):150-152. |
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| 作者姓名： | 席庆 周育森 陈万荣 潘英 丁美 于虹 步荣发 |
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| 作者单位： | 1. 解放军总医院口腔医学中心,北京,100853
2. 军事医学科学院五所分子病原学实验室,北京,100071 |
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| 摘 要： | 目的:研究口腔舌体高分化鳞状细胞癌角蛋白谱的特点。方法:舌体高分化鳞状细胞癌及正常舌体组织活检标本,提取角蛋白,进行SDS-PAGE电泳和利用免疫印迹(Western-blot)杂交方法对比研究舌体高分化鳞状细胞癌及正常舌体组织中角蛋白谱的表达。结果:舌体高分化鳞状细胞癌中出现了单层上皮角蛋白如CK18、19。结论:舌体高分化鳞状细胞癌变异性表达的CK18、19和CK10的不表达,是舌癌发生演变过程的结果,舌癌角蛋白谱的变化与肿瘤的变化有密切关系,可以作为研究肿瘤生物学特征的重要指标。
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| 关 键 词： | 舌 癌 鳞状细胞 角蛋白 分离和纯化 |
| 文章编号： | 1672-2973（2007）03-0150-03 |
| 修稿时间： | 2007-04-30 |
Cytokeratin proteinogram analysis of lingual well-differentiated squamous cell carcinoma |
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| XI Qing,ZHOU Yu-sen,CHEN Wan-rong,PAN Ying,DING Mei,YU Hong,BU Rong-fa.Cytokeratin proteinogram analysis of lingual well-differentiated squamous cell carcinoma[J].Chinese JOurnal of Geriatric Dentistry,2007,5(3):150-152. |
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| Authors: | XI Qing ZHOU Yu-sen CHEN Wan-rong PAN Ying DING Mei YU Hong BU Rong-fa |
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| Institution: | Stomatology center of Chinese, PLA General Hospital, Beijing 100853, China |
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| Abstract: | Objective: To analyse cytokeratin proteinogram of lingua well-differentiated squamous cell carcinoma. Methods: Specimens of lingual well-differentiated squamous cell carcinoma and normal tongue tissue were investigated by immunohistochemistry,SDS PAGE and Western blotting. Results: CK18,19 were detectable in lingua well-differentiated squamous cell carcinoma, differentiated cancerous cells. Conclusions: Aberrant expression of CK18 and 19 and non-expression of CK 10 is a common feature in oral squamous cell carcinoma. These observations suggest that tumours recapitulate common patterns of cytokeratin expression during oral carcinogenesis. The changes of cytokeratin proteinogram of lingual squamous cell carcinoma would be the important oncobiological characteristic figure. |
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| Keywords: | tangue carcinoma squamous cell keratin abstraction and purification |
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