CD24蛋白在膀胱癌中的表达及意义

目的探讨CD24蛋白在膀胱癌中的表达及其与膀胱癌临床特征的关系。方法采用免疫组化方法对43例膀胱肿瘤、10例正常膀胱组织中CD24的表达进行检测。结果CD24蛋白主要表达于膀胱恶性肿瘤细胞的细胞膜和胞浆中，其阳性例数为27例，阳性率为62．8％，在正常膀胱组织中1例阳性表达，阳性率10％。在43例膀胱肿瘤石蜡标本中，CD24表达强度与肿瘤分级和分期有关，恶性程度高的肿瘤阳性表达高于恶性程度低的肿瘤，浸润性癌也高于非浸润性癌（P〈0．05）。结论①CD24在膀胱癌中的表达明显高于在正常膀胱组织中的表达。②CD24高表达与膀胱移行细胞癌的分化和浸润性进展密切相关。③CD24高表达可能成为判断膀胱移行细胞癌预后的一个重要指标。

Clinical significance of CD24 protein expression in human bladder carcinoma

Objective To investigate the clinical significance of CD24 protein expression in human bladder carcinoma. Methods Immunohistochemical method was used in detecting CD24 in 43 TCCB, 10 normal bladder mucosa. Results CD24 protein was mainly localized at cellular membrane and cytoplasm of malignant cell （ positive case was 27）, but only one case expressed in normal bladder mucosa （ n = 10 ）. The intensity of CD24 expression was associated with tumor grade and stage in 43 paraffin embedded specimens of BTCC. The level of CD24 expression was higher in grade Ⅲtumor than in grade I, and it was higher in invasive tumor（ T1 -T4 ） than noinvasive tumor（Ta） （ P 〈 0.05 ）. Conclusions The expression of CD24 is significantly higher in TCCB than in normal bladder tissue. The high expression of CD24 is extremely associated withtumor cells differentiation and invasion in bladder carcinoma. CD24 may be a reliable prognostic marker in bladder transitional cell carcinoma.