小儿肾病综合征还原型谷胱甘肽和总抗氧化能力的变化

目的研究单纯型肾病综合征患儿的红细胞浆还原型谷胱甘肽（GSH）和总抗氧化能力（T—AOC）的变化。方法动态检测26例单纯型肾病综合征患儿（包括活动期和缓解期）红细胞浆GSH和T—AOC的含量。结果单纯型肾病综合征患儿红细胞浆的GSH和T—AOC存在动态变化，缓解期GSH和总抗氧化能力明显要高于疾病活动期（包括初发和复发）的水平（P〈0．01），GSH与总抗氧化能力呈正相关（r=0．87，P〈0．01）。在缓解期，频繁复发组平均GSH和T—AOC水平要低于非频繁复发组（P〈0．01）。结论小儿单纯型肾病综合征患儿在疾病不同时期存在GSH和T—AOC水平变化，能有效提高细胞谷胱甘肽水平进而改善总抗氧化能力，有利于减少复发。

Clinical study on the change of reduced glutathione and total antioxidative capacity in child nephrotic syndrome

Objective To investigate the change of reduced glutathione （GSH）and total antioxidative capacity （T - AOC）in child nephrotic syndrome. Methods Twenty - six cases of nephrotie syndrome were studied about 1 year. The dynamic changes in red blood cell of GSH and T - AOC were observed in active stage and remission. Results GSH and T - AOC levels in active stage were significantly decreased compared with the levels in remission （ P 〈 0.01 ）. The levels of GSH and T - AOC had rectilinear correlation（ r =0.87, P 〈0.01 ）. The group who had frequently relapse mani- fest lower levels of GSH and T - AOC vs. controls group （ P 〈 0.01 ）. Conclusions There are dynamic changes of GSH and T - AOC levels in different stage of child nephrotie syndrome. Effective to elevate the level of GSH and then T - AOC may be beneficial reduce relapse.