| 人胃癌组织中VEGF-C及其受体Flt-4的表达 |
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| 引用本文： | 李玉兰,徐晶莹,张雅芳,李益民,吕岩红,杨树才,赵玲辉.人胃癌组织中VEGF-C及其受体Flt-4的表达[J].中国临床解剖学杂志,2006,24(4):422-424. |
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| 作者姓名： | 李玉兰 徐晶莹 张雅芳 李益民 吕岩红 杨树才 赵玲辉 |
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| 作者单位： | 哈尔滨医科大学人体解剖学教研室,哈尔滨150086 |
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| 基金项目： | 黑龙江省卫生厅科研项目;黑龙江省科技厅科技攻关项目;黑龙江省教育厅科学技术研究项目 |
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| 摘 要： | 目的：观察VEGF-C和Fit-4在胃癌组织及淋巴管的表达，探讨癌细胞淋巴管转移机理。方法：用免疫组化方法检测人胃癌早期和进展期癌细胞和淋巴管VEGF-C和Fit-4的表达情况。结果：在各期胃癌的癌细胞中均见到VEGF-C和Fit-4阳性表达，淋巴管内皮细胞仅见到Fit-4阳性表达；进展期胃癌两种蛋白的表达率和表达强度都高于早期癌。结论：癌细胞VEGF-C和Fit-4的表达与肿瘤进展呈正相关；淋巴管上Fit-4的表达也与胃癌的进展呈正相关。推测VEGF-C可能通过其受体Fit-4诱导胃癌组织淋巴管发生。
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| 关 键 词： | 胃癌 免疫组化 |
| 文章编号： | 1001-165X（2006）04-0422-03 |
| 收稿时间： | 2005-10-14 |
| 修稿时间： | 2005年10月14 |
The expression of VEGF-C and Flt-4 in human gastric cancer |
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| LI Yu-lan, XU Jing-ying, ZHANG Ya-fang,et al..The expression of VEGF-C and Flt-4 in human gastric cancer[J].Chinese Journal of Clinical Anatomy,2006,24(4):422-424. |
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| Authors: | LI Yu-lan XU Jing-ying ZHANG Ya-fang |
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| Institution: | Department of Anatomy, Harbin Medical University, Harbin 150086, China |
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| Abstract: | Objective:To study the expression of VEGF-C and Flt-4 in tissues and lymphoducts of gastric cancer and elucidate the mechanism of lymphatic metastasis of cancer cell. Methods:To examine the expression of VEGF-C and Flt-4 in cancer cells and lymphatics of primary and developing gastric cancers by immunohistochemical staining. Results: Both VEGF-C and Flt-4 expressed at every stage of gastric cancer. Only Flt-4 expression can be observed in endothelial cells of lymphatics. The rate and intension of VEGF-C and Flt-4 proteins expression were higher in developing cancers than in primary cancers. Conclusions:The expression intension of VEGF-C and Flt-4 in cancer cells, as well Flt-4 in lymphatics, has positive correlation with the cancer developing. It suggests that VEGF-C may induce lymphatics generation by its receptor Flt-4. |
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| Keywords: | VEGF-C Flt-4 |
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