^aInstitute of Biopharmaceutical Sciences, Tainan, Taiwan

^bInstitute of Biochemistry and Molecular Biology, Tainan, Taiwan

^cInstitute of Basic Medical Sciences, Medical College, National Cheng Kung University

^dDepartment of Anesthesiology,Tainan, Taiwan

^eDepartment of Surgery, Tainan, Taiwan

^fDepartment of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan