| ATM基因与大肠癌放射敏感性关系的研究进展 |
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| 引用本文： | 李革. ATM基因与大肠癌放射敏感性关系的研究进展[J]. 世界华人消化杂志, 2012, 0(25): 2337-2340 |
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| 作者姓名： | 李革 |
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| 作者单位： | 延边大学附属医院胃肠外科 |
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| 基金项目： | 国家自然科学基金资助项目,No.30960368;吉林省卫生厅基金资助项目,No.2011-1~~ |
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| 摘 要： | 共济失调毛细血管扩张症因ATM基因发生突变所致,一个主要特征是对放射线极度敏感,使ATM成为研究辐射增敏的一个重要的契入点.ATM基因位于人类染色体的11q22-q23,其蛋白主要参与DNA的损伤识别和修复、细胞周期的调控.本文将就有关ATM基因的结构功能及与大肠癌放射敏感性关系的研究进行相关综述.
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| 关 键 词： | ATM 放射敏感性 大肠癌 |
Progress in understanding the relationship between ATM gene and radiosensitivity of colorectal cancer |
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| Ge Li. Progress in understanding the relationship between ATM gene and radiosensitivity of colorectal cancer[J]. World Chinese Journal of Digestology, 2012, 0(25): 2337-2340 |
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| Authors: | Ge Li |
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| Affiliation: | Ge Li,Department of General Surgery,Yanbian University Hospital,Yanji 133000,Jilin Province,China. |
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| Abstract: | Ataxia telangiectasia(AT) is an autosomal recessive disease,and the responsible gene is ATM.One clinical characteristic of AT is exquisite radiosensitivity to ionizing radiation.The ATM gene has been one of the most important targets in radiobiology field that are used to elucidate the mechanisms of radiosensitivity and radioresistance.This gene is located on human chromosome 11q22-q23 and is involved in the repair of DNA damage and regulation of cell cycle checkpoints.This article reviews the structure and functions of the ATM gene and the relationship between ATM and radiosensitivity of colorectal cancer. |
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| Keywords: | Ataxia telangiectasia Radiosensitivity Colorectal cancer |
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