PTH_(1-34)与种植体骨结合相关性的研究进展

骨结合是影响种植体质量的主要因素。它包括初期种植体与牙槽骨之间的机械嵌合和后期种植体周期骨组织的新生与改建。种植材料的生物相容性,种植体的表面结构与性能,种植体植入手术的创伤,种植床的愈合能力,种植体的负荷状况等都会对种植体骨结合的质量产生影响。PTH_(1-34)作为一种针对骨的蛋白合成剂,短期成骨效果明显,促进骨结合形成,在口腔种植领域具有广阔的应用前景。本文从PTH_(1-34)在骨结合方面的基础实验及临床应用进行综述。

Advances in the correlation between PTH1-34 and implant osseointegration

It is the osseointegration that mainly affects the quality of oral implants. The osseointegration includes 1) the mechanical chimera between the early implant and alveolar bone, and 2) the neogenesis and rebuilding of the bone tissue surrounding the late im-plant. The implant osseointegration is affected by various factors such as the biological compatibility of implant materials, the surface structures and properties of implants, the implant surgery trauma, the healing ability of implant beds, and the implant load conditions. As an anabolic agent to bone, PTH1-34 is effective for bone formation in a short time, and it can accelerate the formation of osseointegra-tion. Therefore, PTH1-34 can be widely used in oral implants. This article reviews the basic experiments and clinical applications con-cerning PTH1-34 in implant osseointegration.