代谢组学在牙周病学中的应用

牙周炎是一种以牙周组织破坏为特征的慢性炎症性疾病,牙菌斑生物膜是其发病的始动因子,此外牙周炎还受局部促进因素的影响和全身因素的调控,但其具体的发病机制尚不完全清楚。近年来,随着代谢组学的兴起和发展,探索牙周疾病的致病过程和机理有了新的切入点。本文就代谢组学的概念、特点、检测手段以及代谢组学技术在牙周病学中的应用作一综述。

Applications of metabonomics in periodontology

Periodontitis is a chronic inflammatory disease characterized by the destruction of periodontal tissues. Dental plaque is the dominant pathogenic factor. In addition, periodontitis is also influenced by local contributing factors and systemic factors. The specific pathogenesis has not yet been clarified. Recently, with the rapid development of metabonomics, there has been a new point of penetra-tion to explore the mechanism of periodontitis. In this article, the concept, characteristics, detecting method and the application of metabonomic in periodontitis were reviewed.