| 血脂康对大鼠心肌缺血再灌注损伤的保护作用 |
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| 引用本文： | 滕蕾,张雪娟,聂毛晓. 血脂康对大鼠心肌缺血再灌注损伤的保护作用[J]. 青岛大学医学院学报, 2010, 46(4): 352-353,356. DOI: 10.3969/j.issn.1672-4488.2010.04.023 |
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| 作者姓名： | 滕蕾 张雪娟 聂毛晓 |
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| 作者单位： | 青岛大学医学院附属医院心内科,山东,青岛,266003 |
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| 摘 要： | 目的探讨血脂康对大鼠急性心肌缺血再灌注损伤的保护作用。方法健康SD大鼠20只,随机分为缺血再灌注组(MIR组)及血脂康组。血脂康组行心肌缺血再灌注处理前每天每只大鼠灌喂血脂康胶囊0.09 g/kg,连续7 d,MIR组灌胃等量生理盐水;然后两组结扎冠状动脉左前降支,局部缺血30 min,后行120 min血液再灌注。实验结束前伊文蓝、四氮唑蓝染色,测定梗死心肌的面积;腹主动脉取血,测定肌酸激酶同工酶(CK-MB)、肌红蛋白(MYO)及肌钙蛋白I(cTnI)的含量,同时检测血清白细胞介素18(IL-18)、白细胞介素10(IL-10)、C反应蛋白(CRP)的含量。结果与MIR组相比,血脂康组心肌梗死面积明显减小,CK-MB、MYO、cTnI、IL-18、CRP水平明显降低,IL-10水平显著增加,差异均有统计学意义(t=2.51~12.06,P<0.05)。结论血脂康通过减轻炎症反应降低急性心肌缺血再灌注损伤大鼠的心肌梗死面积,对缺血再灌注损伤具有保护作用。
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| 关 键 词： | 心肌 再灌注损伤 炎症 大鼠 |
PROTECTION OF XUEZHIKANG IN RATS WITH MYOCARDIAL ISCHEMICAL REPERFUSION INJURY |
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| TENG LEI,ZHANG XUE-JUAN,NIE MAO-XIAO. PROTECTION OF XUEZHIKANG IN RATS WITH MYOCARDIAL ISCHEMICAL REPERFUSION INJURY[J]. Acta Academiae Medicinae Qingdao Universitatis, 2010, 46(4): 352-353,356. DOI: 10.3969/j.issn.1672-4488.2010.04.023 |
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| Authors: | TENG LEI ZHANG XUE-JUAN NIE MAO-XIAO |
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| Affiliation: | TENG LEI,ZHANG XUE-JUAN,NIE MAO-XIAO(Department of Cardiology,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China) |
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| Abstract: | Objective To investigate the protection of Xuezhikang capsules in rats with acute myocardial ischemial reperfusion injury(AMIRI). Methods Twenty healthy SD rats were randomly divided into two groups: myocardial ischemia reperfusion group(MIR group) and Xuezhikang group: the rats in Xuezhikang group were treated with Xuezhikang(0.09 g/kg,gastric gavage) and those in MIR group were treated with the same amount of normal saline,for seven days.The rats of the two groups were subjected to 30 minutes of ischemia ... |
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| Keywords: | myocardium ischemia-reperfusion injury inflammations rats |
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