EFFECTS OF INTRACAROTID ADMINISTRATION OF β-PHENYL-γ-AMINOBUTYRIC ACID ON THE PERFUSED CAT BRAIN |
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| Authors: | Saburo OTSUKI Shosuke WATANABE Kazuyasu EDAMATSU Yoshihiko NAKASHIMA Takayuki HOAKI Kiyoaki NINOMIYA Katsusuke MITSUNOBU Takanori SANNOMIYA Nikichi OKUMURA |
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| Affiliation: | Department of Neuropsychiatry, Okayama University Medical School, Okayama, Japan |
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| Abstract: | An investigation was carried out on the effects of intracarotid administration of β-phenyl-γ-aminobutyric acid (β-phenyl-GABA) on the functions of a perfused cat brain. After injecting one ml, each of containing 1, 5, 10, 20, 25, or 35mg/ml of β-phenyl-GABA into the tubes perfusing the carotid arteries with standard artificial blood, the acute effects of the drug on EEG, cerebral blood flow, and oxygen consumption were observed. The results may be briefly summarized as follows. - 1). EEG is inhibited shortly after the drug reaches the brain. The extent of inhibition rises and the duration of the inhibition is longer as the dose is increased.
- 2). β-phenyl-GABA increases the cerebral blood flow in the cat brain and the increase reaches its maximum with a dose of 5 mg. Above this dose it declines.
- 3). This drug increases the oxygen consumption of the brain slightly.
- 4). It has no effect on the systemic blood pressure.
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