结节病病人血清抗布氏疏螺旋体抗体测定及其意义

用酶联免疫检测法（ＥＬＩＳＡ）测定４０例患者血清抗布氏疏螺旋体（ＢｏｒｒｅｌｉａＢｕｒｇｄｏｒｆｅｒｉ，简称ＢＢ）抗体水平，其中结节病２３例，非结节病１７例。结节病病人血清抗ＢＢ抗体阳性１８例，占７８．３％，非结节病病人阳性１３例，占７６．５％。初步认为结节病可能是一种自身免疫异常疾病，血清抗ＢＢ抗体可能是机体对某种不明抗原刺激所产生的一种自体抗体，与风湿病、结核病、肿瘤和莱姆病可能存在着交叉反应；但是否有另外一种可能：即ＢＢ抗原本身是一种混合物，不同疾病中的不同抗体与ＢＢ抗原中的不同组分起反应？因此，ＢＢ抗体不能作为诊断结节病的特异性指标。

DETERMINATION OF ANTIBODY OF BORRELIA BURGDOFERI IN THE SERUM OF PA-TIENTS WITH SARCOIDOSIS AND ITS SIGNIFICANCE

he level of antibody of Borrelia Burgdoferi in the serum of 40 patient,23 with sarcoidosis and 17 without sarcoidosis was detennined by using ELISA method Antibody of BB was positive in the serum of 18 patients with sarcoidosis(78.3%).It is possible that sarcoidosis might be a disease of autoimmune abnormality and antibody of BB in the serum an auto-antibody resulting from the stimuli of certain unknown antigens. Cross reactivity may be present between the serological tests for sarcoidosis and those for rheumatic disease tuberculosis,tumour and Lyme disease. But another case might be th atantigen of BB is a mixture. Different antibodies of different disease react with different component of antigen of BB. Therefore,antibody of BB can not be considered as a specific test in the diagnosis of sarcoidosis.