血小板活化在运动所致心肌缺血中的临床意义

采用放射免疫法测定５５例冠心病患者和２０例健康人踏车试验（ＥＴ）前后血小板膜表面α－颗粒膜蛋白（ＧＭＰ－１４０）分子数和血浆血栓素Ｂ＿２（ＴＸＢ＿２）浓度变化。结果显示，冠心病组３６例ＥＴ阳性，１９例ＥＴ阴性，正常对照组２０例ＥＴ均阴性。冠心病ＥＴ阳性组运动后即刻血小板膜表面ＧＭＰ－１４０、血浆ＴＸＢ＿２较运动前明显升高（Ｐ＜０．０５）。冠心病ＥＴ阴性组和正常对照组运动前后血小板膜表面ＧＭＰ－１４０、血浆ＴＸＢ＿２差异无显著性（Ｐ＞０．０５）。提示血小板活化可能是运动所致心肌缺血的重要因素。

THE CLINICAL SIGNIFICANCE OF PLATELET ACTIVATION DURING EXERCISE-IN-DUCED MYOCARDIAL ISCHEMIA

he levels of alpha-granule membrane protein(GMP-140)on the surface of platelet and serumTXB_2 were determined in 55 patients with coronary heart disease(CHD) and 20 healthy individuals be-fore and after exercise test.Among the 55 CH D patients, 36 had positive and 19 had negativeresults.The number of GMP-140 molecules on the platelet surface and serum TXB_2 level weresignificantly increased in the patients with positive exercise test,P<0.05. The increase was transientand GMP- 140 returned to the preexercise level 15 minutes after the exercise test. In contrast,GMP-140 and TXB_2 levels were not elevated in CHD patients with negative exercise test and also innoimal subjects after exercise.The result indicates that platelet activation may be related to theexercise-induced myocardial ischemia in CHD patients.