Ki-67和CD44v5在卵巢癌中的表达和临床意义

目的 研究ki-67和CD44v5在卵巢癌中的表达及临床意义。方法 用免疫组化sp法研究ki-67和CD44v5在40例卵巢癌手术切除标本及10例卵巢上皮良性肿瘤中的表达。结果 40例卵巢癌中，ki-67和CD44v5的阳性表达率分别为77．5％和47．5％，远高于在卵巢上皮良性肿瘤中的表达30．0％和20．0％。且随着肿瘤病理分化程度的降低，ki-67、CD44v5阳性表达率均呈增高趋势；ki-67在卵巢腺癌中的阳性表达率明显高于透明细胞癌、内膜样癌（P〈0．05）；CD44v5的阳性表达率与表达强度伴淋巴转移者显著高于无淋巴转移者（P〈0．01）；两者呈正相关。结论 ki-67和CD44v5在卵巢癌中的表达对卵巢癌的诊断、治疗方式的选择、手术范围的确定、及术后防治复发、化疗药物的应用，具有重要的指导意义。

Expression of ki-67 and CD44v5 in patients with ovarian cancer and its clinical significance

Objective:To study the expressions of ki-67 and CD44v5 in patients with ovarian cancer,and its clinical significance.Methods:The expressions of ki-67 and CD44v5 were determinded in 40 cases of ovarian cancer and 10 cases of normal ovarian tissue individual with immunohistochemical S-P method.Results:The expression rate of ki-67 and CD44v5 in 40 ovarian cancer samples was 77.5% and 42.5%,significantly higher than that in 10 cases of normal ovarian tissue individual(30.0% and 20.0%).In 40 ovarian cancer samples,The expression rate of ki-67 and CD44v5 both rise with the developing of ovarian cancer;The expression rate of ki-67 in 31 ovarian cystadenocarcinoma significantly higher than that in other 9 ovarian cancer samples(P<0.05=;The expression rate and intensity of CD44v5 in patients with tumorlymphoid metastasis were significantly higher than those without lymphoid metastasis(P<0.01=.Conclusion:It is helpful to measure the expression of ki-67 and CD44v5 in ovarian cancer for the diagnosis,treatment,deciding opration range,prevention and cure relapse after the opration and the amount of medicament.