原发性肝癌血清雌二醇含量与肝组织雌二醇受体的初步研究

应用放免法测定肝癌组,肝硬化组及正常对照组血清雌二醇的含量,并对10例肝癌,18例肝硬化进行了雌二醇受体的组织化学检查。结果表明;雌二醇受体主要分布于肝癌的癌细胞浆内,受体阳性例数较肝硬化例明显减少,着色强度明显减弱。肝癌患者血清雌二醇含量明显低于肝硬化及正常对照组。肝癌血清雌二醇含量与组织内雌二醇受体阳性细胞百分比无平行关系。认为不能以血清雌二醇含量估计组织内相应受体的多少。

A PRELIMINARY STUDY GF SERUM IEVEIS OF ESTRADIOL AND ESTRCGEN RECEPTORS IN LIVER CIRRHORSIS AND PRJMARY LIVER CARCJNCMA

The serum levels of estradicl in 23 patients with liver cirrhosis (LC), and 22 patients with primary liver carcinoma (PLC) were determined by radioimmuncassay. Estrogen receptors of liver tissue in 18 patients with LC and 10 patients with PLC were determined histochemically. The results showed that the serum levels of estradiol in LC was significantly higher than the control group (P<0.05) and PLC group. It was supposed that the activity of 5-reducase increased in LC and more androgen were transformed into estrogens. The serum levels of estradiol in PLC was significantly lower than the control group (P<0.01), it might be related to the function disorder of hypothalamus and pituitary. About estrogen receptors, 14 of the 18 patients with LC and 4 of the 10 patients with PLC showed positive reaction. The positive cases of estrogon receptors in PLC decreased significantly than in LC (P<0.05). The positive colouring intensity in PLC of estrogen receptors in PLC was weakened. Compared with LC, estrogen receptors were mainly distributed in liver tissue of LC and cytoplasm of cancer cells of PLC. The densely covered estrogen receptors were found in LC but scattered cluster in PLC. There was no parallel relationship between serum levels of estradiol and the positive ratio of estrogen receptors in liver disease. It is postulated that we can not evaluate the quantity of estrogen receptors in liver tissue in line with serum levels of estradiol.