| 葛根素对局灶性脑缺血再灌注模型大鼠脑组织水肿及神经细胞Na+ -K+ -ATPase、Ca2+-ATPase活性的影响 |
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| 引用本文： | 王玉,朱慧渊,郭莹,韩进,万海同.葛根素对局灶性脑缺血再灌注模型大鼠脑组织水肿及神经细胞Na+ -K+ -ATPase、Ca2+-ATPase活性的影响[J].中国中医急症,2007,16(1):70-71. |
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| 作者姓名： | 王玉 朱慧渊 郭莹 韩进 万海同 |
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| 作者单位： | 浙江中医药大学心脑血管病研究所,杭州,310053 |
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| 基金项目： | 国家自然科学基金;浙江省自然科学基金 |
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| 摘 要： | 目的探讨葛根素对脑缺血再灌注损伤保护作用的机制。方法采用大鼠大脑中动脉栓塞模型（MCAO），观察葛根素对脑缺血再灌注脑组织水肿及神经细胞Na^＋-K^＋-ATPase、Ca^2＋-ATPase活性的影响。结果葛根素能明显降低MCAO大鼠脑含水量，提高Na^＋-K^＋-ATPase、Ca^2＋-ATPase活性。结论大鼠MCAO后脑组织水肿明显，ATPase活性降低；葛根素可以减轻此类损伤，对脑组织具有保护作用。
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| 关 键 词： | 葛根素 脑缺血再灌注 大鼠 |
| 文章编号： | 1004-745X（2007）01-0070-02 |
| 收稿时间： | 2006-06-09 |
| 修稿时间： | 2006年6月9日 |
The Influence of Puerarin on the Brain Edema and the Activity of Na+ -K + -ATPase, Ca2 + -ATPase in Neuron of Ischemia-Reperfusion Rats |
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| WANG Yu, ZHU Hui-yuan, GUO Ying, et al.The Influence of Puerarin on the Brain Edema and the Activity of Na+ -K + -ATPase, Ca2 + -ATPase in Neuron of Ischemia-Reperfusion Rats[J].Journal of Emergency in Traditional Chinese Medicine,2007,16(1):70-71. |
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| Authors: | WANG Yu ZHU Hui-yuan GUO Ying |
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| Institution: | The Institute of Cardiovascular and Cerebrovascular Disease, Zhejiang University of TCM (Hangzhou, 310053 |
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| Abstract: | Objective:To explore the protective mechanism of Puerarin on cerebral ischemia-reperfusion injury. Methods:The ischemia-reperfusion model rats was induced by means of middle cerebral artery occlusion(MCAO), the brain edema and Na+-K+-ATPase,Ca2+ATPase activity in neuron were measured to study the effect of Perarin against cerebral ischemia-reperfusion injury.Results:Puerarin can significant decrease the brain edema in rats induced by MCAO,and increase the activity of Na+K+-ATPase,Ca2+-APTase.Conclusions:The brain edama is obviously increased and the activity of ATPase is obviously decreased after MCAO.Puerarin can alleviate the injuriy and has the neuro-protective effect against ischemia-reperfusion injury. |
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| Keywords: | MCAO |
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