| 双酚A致体外培养大鼠胚胎发育毒性的时间-效应关系研究 |
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| 引用本文： | 谢军,李小玲,陈宏.双酚A致体外培养大鼠胚胎发育毒性的时间-效应关系研究[J].实用预防医学,2010,17(8):1649-1651. |
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| 作者姓名： | 谢军 李小玲 陈宏 |
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| 作者单位： | 1. 湖南省益阳市疾病预防控制中心,湖南,益阳,413000
2. 南华大学公共卫生学院 |
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| 摘 要： | 目的探讨双酚A（BisphenolA）对大鼠胚胎毒性的时间-效应关系。方法采用全胚胎培养模型,对9.5d龄大鼠胚胎分别染毒BisphenolA（100mg/L）6、16、26、48h,观察体外培养胚胎生长发育的影响。结果早期暴露6h对体外培养的大鼠胚胎的生长发育无不良影响,染毒16h即可影响大鼠胚胎的生长发育,染毒26h和48h对胚胎生长发育和形态分化均有明显的抑制作用。光镜下发现只有染毒26h以上才出现卵黄囊及大鼠胚胎脑组织结构的改变。结论体外实验条件下,BPA对器官形成期的早期大鼠胚胎的毒性作用具有明显的时间-效应关系,其毒性表现为慢性毒性作用。
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| 关 键 词： | 双酚A 全胚胎培养 发育毒性 胚胎毒性 时间-效应关系 |
In Vitro Study on Time-effect Relationship of Bisphenol A-induced Toxicity on the Embryo Development of Rats |
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| XIE Jun,LI Xiao-ling,CHEN Hong.In Vitro Study on Time-effect Relationship of Bisphenol A-induced Toxicity on the Embryo Development of Rats[J].Practical Preventive Medicine,2010,17(8):1649-1651. |
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| Authors: | XIE Jun LI Xiao-ling CHEN Hong |
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| Institution: | XIE Jun,LI Xiao-ling,CHEN Hong(Yiyang Municipal Center for Disease Control and Prevention,Yiyang 413000,Hunan,China) |
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| Abstract: | Objective To explore the time-effect relationship of 4-nonylphenol(Bisphenol A)-induced rat embryonic toxicity in vitro.Methods 9.5-day isolated rat embryos were exposed at 100 mg/L Bisphenol A for 6,16,26,and 48 hours by means of whole embryo culture(WEC)technique.Results At the early 16 h stage of 48 h culture,the values of some parameters connected with embryo growth and morphogenesis were lower than those of control group(P<0.05).After 26 h or 48 h exposure,most indexes of embryo growth and morphologica... |
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| Keywords: | Bisphenol A Whole embryo culture Developmental toxicity Embryo toxicity Time-effect relationship |
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