PTEN蛋白在胃癌组织中的表达及其临床意义

目的：探讨胃癌组织中PTEN蛋白表达及其临床意义。方法：收集53例胃癌和30例慢性胃炎用免疫组化方法检测PTEN蛋白的表达。结果：胃癌和慢性胃炎中PTEN蛋白阳性率分别为67．9％、1013．0％，胃癌中PTEN蛋白的阳性率低于慢性胃炎组织（P〈0．05）。在高、中、低分化胃腺癌中，PTEN阳性率分别为88．9％、70．6％、44．4％，随分化程度的降低，FTEN阳性表达率降低，高分化与低分化之间差异显著（P〈0．05）。胃癌伴有淋巴结转移者，PTEN阳性率55．2％，不伴有淋巴结转移者，阳性率83．3％，两者之间差异显著（P〈0．05）。结论：PTEN在胃癌的诊断、组织学分级、淋巴结转移中有重要价值。PTEN蛋白低表达可能参与了胃癌的发生、发展及淋巴结转移，将有可能作为判断胃癌预后不良的参考指标。

Expression of PTEN protein in gastric cancer and its clinical significance

Objective：To explore the expression of PTEN protein in gastric cancer tissues and its clinical significances. Methods ： The expression of PTEN protein was detected by immunohistochemistry in 53 cases of gastric cancer and 30 cases of chronic gastritis. Results： The positive rate of expression of PTEN protein in gastric cancer and chronic gastritis was 67.9% and 100. 0% respectively. The positive rate of PTEN protein in gastric cancer was lower than that of chronic gastritis. There were significant difference between gastric cancer and chronic gastritis （ P 〈 0. 05 ）. The positive rate of expression of PTEN protein in the high, middle and low differentiated grade of the carcinoma was 88. 9% , 70. 6% , 44. 4% , respectively. The lower the differentiation of the gastric cancer, the lower the positive rate of PTEN protein was. There was significant differences between high and low differentiated grade of the cancer（ P 〈 0. 05 ）. The positive rate of expression of PTEN protein was 55.2% in patients with lymph node metastasis, and the positive rate of expression of FFEN protein was 83.3% in patients without lymph node metastasis. There were significant differences（ P 〈 0. 05 ）. Conclusion ： There is a notable relevance between the low expression of PTEN protein and lymph node metastasis. PTEN has great values in the histopathologic grade of gastric cancer, diagnosis and lymph node metastasis. The low expression of PTEN could be used as a bad prognostic factor for gastric cancer.