OSAHS并发2型糖尿病患者血浆ET-1和血清NO测定及其与血糖和睡眠呼吸暂停指数的相关性分析

目的：探讨检测阻塞性睡眠呼吸暂停低通气综合征(OSAHS)并发2型糖尿病患者血清一氧化氮(NO)、血浆内皮素1(ET-1)与管内皮细胞功能失调的相关性，为临床进行血管内皮保护提供理论根据。方法： OSAHS患者42例，2型糖尿病患者38例，OSAHS并发2型糖尿病患者32例，经多导睡眠监测系统(polysomnography,PSG)及空腹血糖检测确诊。所有入选者在睡眠监测结束，晨醒10 min内采取肘静脉血，检测血浆ET-1及血清NO。结果：OSAHS并发2型糖尿病组与OSAHS组和糖尿病组患者比较，血浆ET-1浓度升高(P<0.05)，血清NO 浓度及NO/ET-1比值降低(P<0.05)。直线相关分析显示，糖尿病组患者血浆ET-1水平与血糖呈正相关(r=0.729，P<0.05)，血清NO水平与血糖呈负相关(r=－0.586,P<0.05)；OSAHS组患者血浆ET-1水平与睡眠呼吸暂停指数(AHI)呈正相关(r=0.820,P<0.05)，血清NO水平与AHI呈负相关(r=－0.734,P<0.05)。结论：OSAHS并发2型糖尿病患者与OSAHS患者和糖尿病患者比较，血浆ET-1浓度升高，血清NO 浓度、NO/ET-1比值降低，说明OSAHS并发2型糖尿病患者血管内皮受损程度更加严重。

Determination of levels of plasma ET-1 and serum NO in patients with OSAHS complicated with type 2 diabetes and correlation analysis on fasting blood sugar and AHI

Objective To study the relationship between the unbalance of internal environment of blood vessel and obstructive sleep apnea-hypopnea syndrome (OSAHS)compliated with type 2diabetes and provide a theoretical basis for protection of the blood vessel endodermis.Methods 42patients with OSAHS,38patients with type 2 diabetes and 32patients with OSAHS complicated with type 2diabetes were selected,all the patients were diagnosed by polysomnography(PSG)and the level of fasting blood sugar.The plasma endothelin (ET-...