Gonadotropin secretion in hyperthyroidism and hypothyroidism |
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Authors: | Giorgio Valenti Gian Paolo Ceda Licia Denti Edoardo Tarditi Guglielmina Speroni |
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Affiliation: | (1) Istituto di Clinica Medica Generale e Terapia Medica, Università degli Studi di Parma, Via A. Gramsci 14, 43100 Parma, Italia |
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Abstract: | Summary Gonadotropin patterns were evaluated in a group of 70 patients of both sexes with Graves’ disease or primary hypothyroidism. Significant variations were found only in hyperthyroidism where increased basal and stimulated values of both gonadotropins, but particularly LH, occurred. Qualitative and quantitative recovery was seen when euthyroid states were achieved after treatment of hyper and hypothyroid patients. Interactions with gonadotropin behavior were found in both sexes and in women of different ages. Direct interference on the hypothalamo-pituitary system rather than through the modulation of peripheral estrogen metabolism is suggested as the possible pathogenetic mechanism. This work was supported by grant CT 81.00372.04/115.4883 from theConsiglio Nazionale delle Ricerche (CNR), Roma, Italy. |
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Keywords: | Gonadotropin-releasing hormone Gonadotropins Hyperthyroidism Hypothyroidism Thyroid hormones |
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