Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis |
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| Authors: | Fredrik Sjövall Saori Morota Magnus J Hansson Hans Friberg Erich Gnaiger Eskil Elmér |
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| Affiliation: | 1.Mitochondrial Pathophysiology Unit, Laboratory for Experimental Brain Research, Department of Clinical Sciences,Lund University,Lund,Sweden;2.Intensive Care Unit 4131,Rigshospitalet,Copenhagen University Hospital,Copenhagen,Denmark;3.Department of Emergency Medicine,Sk?ne University Hospital,Lund,Sweden;4.Department of Emergency Medicine,Sk?ne University Hospital,Lund,Sweden;5.Department of Visceral, Transplant and Thoracic Surgery, D. Swarovski Research Laboratory,Innsbruck Medical University,Innsbruck,Austria;6.Department of Clinical Neurophysiology,Sk?ne University Hospital,Lund,Sweden |
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| Abstract: | Introduction Mitochondrial dysfunction has been suggested as a contributing factor to the pathogenesis of sepsis-induced multiple organ failure. Also, restoration of mitochondrial function, known as mitochondrial biogenesis, has been implicated as a key factor for the recovery of organ function in patients with sepsis. Here we investigated temporal changes in platelet mitochondrial respiratory function in patients with sepsis during the first week after disease onset. |
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