| 肿瘤抑癌基因PTEN在胃癌中的研究进展 |
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| 引用本文： | 巩方明.肿瘤抑癌基因PTEN在胃癌中的研究进展[J].肿瘤研究与临床,2012,24(7):495-497. |
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| 作者姓名： | 巩方明 |
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| 作者单位： | 山东省医学科学院附属医院外二科, 济南,250031 |
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| 基金项目： | 山东省科技厅科技攻关资助项目 |
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| 摘 要： | Pten是迄今发现的第一个具有双特异性磷酸酶活性（脂质磷酸酶、蛋白磷酸酶）的抑癌基因，它主要通过调整细胞周期及信号转导途径来发挥作用。PTEN蛋白在胃癌发生发展不同阶段表达呈进行性下调或缺失，提示PTEN基因的异常改变参与胃粘膜细胞的恶性转化过程，PTEN蛋白表达水平可作为评价胃癌病理生物学行为的客观指标之一。
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| 关 键 词： | [关键词]PTEN 抑癌基因，胃癌 |
Research progress on tumor suppressor gene PTEN in gastric carcinoma |
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| GONG Fang-ming.Research progress on tumor suppressor gene PTEN in gastric carcinoma[J].Cancer Research and Clinic,2012,24(7):495-497. |
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| Authors: | GONG Fang-ming |
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| Institution: | GONG Fang-ruing, LIU Hong-jun. Department of General Surgey, Affiliated Hospital, Shah dong Academy of Medical Science, Jinan 250031, China |
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| Abstract: | PTEN is a tumor suppressor with double specific phosphatase activity,and PTEN brings into its lipid and protein phosphatase activity through PIP3 , FAK, MAPK pathway. PTEN also induces apoptosis, inhibits cell growth, and regulates cell migration and adhesiveness. PTEN expression is lower in gastric carcinoma. It may be valuable to evaluate that the abnormal expression of suppressor gene PTEN participates in the malignant conversion process of the gastric mucosa cell, and the expression levels of the PTEN protein can be used to evaluate the pathologic biology behavior of gastric carcinoma. |
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| Keywords: | Stomach pcveoplasms PTEN Tumor suppressor gene |
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