VEGF-C和CD44V6与甲状腺乳头状癌颈淋巴结转移的关系

 摘要]:目的 探讨VEGF-C和CD44V6与甲状腺乳头状癌颈淋巴结转移的相关性。 方法]采用免疫化学SP法检测80例甲状腺乳头状癌患者肿瘤组织的VEGF-C和CD44V6蛋白表达进行检测，其中伴有颈淋巴结转移(N+)的甲状腺乳头状癌患者38例，不伴颈淋巴结转移(N-)的甲状腺乳头状癌患者42例。结果 颈淋巴结转移组甲状腺乳头状癌原发灶标本VEGF-C和CD44V6的表达阳性率分别为:86.84%和81.58%,不伴颈淋巴结转移组甲状腺乳头状癌原发灶标本VEGF-C和CD44V6的表达阳性率分别为：61.9%和52.38% ,两组之间差异有统计学意义(P<0.05)。VEGF-C和CD44V6的表达呈正相关(r=0.525,P<0.01);结论VEGF-C和CD44V6在甲状腺癌淋巴转移中起着重要作用, VEGF-C和CD44V6可作为甲状腺乳头状癌病理生物学行为的观测指标。

Relation of VEGF-C and CD44V6 expression with cervical lymph metastases in papillary thyroid carcinoma

Objective To explore the relation of VEGF-C and CD44V6 expression with cervical lymph metastases in papillary thyroid carcinoma. Methods The expression of VEGF-C and CD44V6 in 80 specimens of papillary thyroid carcinoma were evaluated with SP immunohistochemical methods. Lymphangiogenesis was examined by immunohistochemical staining with tile specific D2-40 antibody and evaluated by lymphatic vessel density（LVD）. In all the 80 cases, there were 38 cases with cervical lymph node metastases and 42 cases without cervical lymph node metastasis. Results The positive expression rates of VEGF-C and CD44V6 in the cases with cervical metastases were 86.84 % （33/38） and 81.58 % （31/38） respectively, and in the cases without cervical lymph metastases were 61.90 % （26/42） and 52.38 % （22/42） respectively. There were significant differences in the positive expression rates of VEGF-C and CD44V6between two groups （P〈0.05）. In the cases with lymph node metastases, there were positive correlations between VEGF-C and CD44V6 expression （r=0.525,P〈0.01）. Conclusion VEGF-C and CD44V6 play important roles in lymph metastasis and invasion of papillary thyroid carcinoma. VEGF-C and CD44V6 can be considered as a marker of pathological and biological behavior of papillary thyroid carcinoma.