c-kit蛋白和Ki-67表达在涎腺基底细胞腺瘤和腺样囊性癌诊断中的意义

 目的　探讨原癌基因c-kit和细胞核增殖抗原Ki-67的表达在涎腺基底细胞腺瘤和腺样囊性癌诊断中的意义。方法　应用免疫组织化学方法检测18例基底细胞腺瘤和42例腺样囊性癌标本中瘤细胞c-kit和Ki-67的表达。结果　18例基底细胞腺瘤和42例腺样囊性癌中c-kit的表达率分别为72.2 %（13／18）和83.3 %（35／42），两者差异无统计学意义（χ2＝0.11，P＞0.05）；18例基底细胞腺瘤和42例腺样囊性癌中Ki-67的平均表达率分别为（3.72±1.41）%和（23.81±10.19）%，两者差异有统计学意义（t＝14.145，P＜0.01）。结论　原癌基因c-kit表达对涎腺基底细胞腺瘤和腺样囊性癌的鉴别诊断无意义， Ki-67 对两者鉴别诊断有意义。

Diagnostic significance of c-kit and Ki-67 expression in the baseal cell adenoma and adenoid cystic carcinom of salivary gland

Objective To study the expression of c-kit and Ki-67 in the basal cell adenoma（BCA） and adenoid cystic carcinoma （ACC） of salivary gland. Methods The expression of c-kit and Ki-67 was determined by immunohistochemistry method in BCA and ACC of salivary gland. Results The positive immuostaining of c-kit in BCA and ACC were 72.2 %（13/18） and 83.3 %（35/42）,respectively, There was no significant difference in the expression of c-kit between the two tissues （x2=0.11, P〉0.05）.The expression of Ki-67 was significantly different between BCA （3.72 ± 1.41 ） % ] and ACC （23.81 ± 10.19） % 1 （ t= 14.145, P〈0.01）. Conclusion Detection of Ki-67 might be helpful to distinguish between BCA and ACC, but c-kit has no effect in differentiating BCA from ACC.