| 诱骗受体3与肿瘤的研究进展 |
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| 引用本文： | 岳庆峰,汪永和.诱骗受体3与肿瘤的研究进展[J].肿瘤研究与临床,2012,24(5):354-357. |
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| 作者姓名： | 岳庆峰 汪永和 |
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| 作者单位： | 230022,合肥市第三人民医院胸外科 |
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| 基金项目： | 合肥市第三人民医院院内基金 |
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| 摘 要： | 诱骗受体3（DcR3）基因在一些肿瘤细胞中表达明显增加，DcR3通过竞争性阻断与Fas／FasL、LIGHT及TL1A／DR3信号通路，调节细胞增殖、抑制细胞凋亡、逃避免疫监视、形成肿瘤血管，与肿瘤的发生、发展密切相关。DcR3有可能成为一种全新的肿瘤特异性标志物，在肿瘤发生、发展、预防、诊断、治疗、预后及疗效观察方面提供一种新的思路，为临床应用揭开新的篇章。
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| 关 键 词： | 肿瘤坏死因子诱骗受体 肿瘤 细胞凋亡 研究 |
Research progress of decoy receptor 3 in cancer |
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| YUE Qing-feng
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WANG Yong-he.Research progress of decoy receptor 3 in cancer[J].Cancer Research and Clinic,2012,24(5):354-357. |
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| Authors: | YUE Qing-feng WANG Yong-he |
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| Institution: | YUE Qing-feng, WANG Yong-he, WEI Xiang-zhi.Third People＇s Hospital Of Hefei, Heifei 230022,China |
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| Abstract: | Decoy receptor 3（DcR3） gene expresses highly in some malignant tumors,it involves cellular proliferation regulation, inhibition of apoptosis, immune escape and tumor angiogenesis by competitively blocking the Fas/FasL, LIGHT and TL1A/DR3 signal pathway , therefore it deeply relates to the malignant tumors＇s generation and progression.DcR3 is supposed to be the new tumor-specific marker that may cast the light to the tumor generation, development, prevention, diagnosis, treatment, prognosis and effect observation. DcR3 is expected to be open a new chapter in clinical application. |
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| Keywords: | Tumor necrosis factor decoy receptors Neoplasms Apoptosis Research |
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