| 二亚硝基哌嗪对大鼠鼻咽鳞状上皮更新的影响 |
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| 引用本文： | 陈主初,潘世宬,孙去病,姚开泰.二亚硝基哌嗪对大鼠鼻咽鳞状上皮更新的影响[J].中南大学学报(医学版),1984(4). |
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| 作者姓名： | 陈主初 潘世宬 孙去病 姚开泰 |
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| 作者单位： | 湖南医学院肿瘤研究室
(陈主初，潘世宬，孙去病)，湖南医学院肿瘤研究室(姚开泰) |
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| 摘 要： | 本文用放射自显影术对正常大鼠以及二亚硝基哌嗪(简称二亚)处理鼠诱癌过程中鼻咽鳞状上皮细胞的更新进行了观察。实验表明,正常情况下,大鼠鼻咽底壁鳞状上皮细胞移动的变化是“S”形曲线,其方程式为 y=ap_0/bp_0 (a-bp_0)e~(-a(x/72));二亚处理后,大鼠鼻咽底壁鳞状上皮细胞移动表现为抛物线,其方程式为 y=a bx cx~2。同时对食道、颊部粘膜的细胞移动进行了观察。
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| 关 键 词： | 鼻咽肿瘤 疾病模型 动物 二亚硝基哌嗪 细胞运动 更新 细胞 大鼠 自体放射显影 |
RENEWAL OF NASOPHARYNGEAL SQUAMOUS EPITHELIUM OF RATS TREATED WITH N,N-DINITROSOPIPERAZINE |
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| Chen Zhuchu Pan Shicheng Sun Qubing Yao KaitaiCancer Rescach Laboratory,Hunan Medical College.RENEWAL OF NASOPHARYNGEAL SQUAMOUS EPITHELIUM OF RATS TREATED WITH N,N-DINITROSOPIPERAZINE[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),1984(4). |
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| Authors: | Chen Zhuchu Pan Shicheng Sun Qubing Yao KaitaiCancer Rescach Laboratory Hunan Medical College |
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| Abstract: | The migration of cells of the nasopharyngeal stratified squamous epithelium was investigated radioautographically in the normal and DNP-treated rats at various intervals after a single injection of thymidine-3H. The results showed that: (1) in normal animals, the pattern of squamous cell migration in the nasopharyngeal ventral wall appeared a sigmoid curve; (2) The cellular renewal was changed in the nasopharynx after DNP treatment in all rats, the migration of squamous cells appeared a parabolic curve. (3) The cell migration of the esophagus and bucca cavioris was not changed in the control and DNP-treated rats. It seems that the change of the cellular migration in the nasopharynx may be related to the effect of DNP. |
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| Keywords: | Nasopharyngeal neoplasms Nitrosammes(dinitrosopiperazine) Disease model animal Ceil movement Renewal cell Autoradiography |
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