盐酸舍曲林联合无抽搐电休克治疗创伤后应激障碍的疗效观察

目的探讨舍曲林联合无抽搐电休克（MECT）治疗创伤后应激障碍的临床疗效。方法将96例创伤后应激障碍患者随机分为研究组和对照组各48例,2组均用舍曲林治疗,研究组联合MECT治疗,每周2~3次,疗程4周。于治疗前及治疗第1、2、3、4周末采用创伤后应激障碍自评量表（PTSD-SS）和简明精神病评定量表（BPRS）评定临床疗效;TESS评定不良反应。结果 （1）研究组治疗第1周末PTSD-SS和BPRS分值明显下降（P〈0.05）,而对照组改变不明显;（2）第2、3、4周末2组PTSD-SS和BPRS分值均下降,2组间差异有统计学意义（P〈0.05或0.01）;（3）第4周末2组的减分率分别为92.15%和81.33%（P〈0.05）,2组不良反应无显著性差异。结论舍曲林联合MECT治疗创伤后应激障碍与单用舍曲林比较,前者治疗效果更好,起效更快,而不良反应无明显差异,值得临床应用。

Control Study of Efficacy of Sertraline Combined with Modified Electric Convulsive Therapy in Treatment of Posttraumatic Stress Disorder

Objective To investigate the clinical efficacy of sertraline in combination with modified electric convulsive therapy（ MECT） in treating post traumatic stress disorder（ PTSD）. Methods 96 cases of PTSD were randomly and equally divided into study group and control group. Both groups were treated with sertraline treatment,while the study group was also trented with MECT two or three times a week for 4 weeks. Before treatment and at the end of week 1,2,3,4,PTSD Checklist（ PTSD-SS） and the Brief Psychiatric Rating Scale（ BPRS） was used to assess the clinical efficacy. Results（ 1） In study group,PTSD-SS and BPRS scores began to decline at the first weekend,while the control group was not much affected（ P〈0. 05）.（ 2） At the end of week 2,3,4,PTSD-SS and BPRS scores decreased in both groups,but there was significant difference between the two groups（ P〈0. 05 or 0. 01）.（ 3） At the 4th weekend,the reduction rate of the two groups was92.15% and 81.33%（ P〈0. 05） respectively.Conclusion The combination of sertraline with MECT in treating PTSD is more effective than sertraline alone.