化疗药物对异位肿瘤合并癌前病变胃组织匀浆中癌胚抗原表达的影响

目的 观察化疗药物对异位肿瘤合并癌前病变者胃组织匀浆中癌胚抗原(CEA)表达的影响.方法 45例肿瘤患者(癌前病变组)化疗前经胃镜检查均有不典型增生或肠上皮化生.在化疗前及化疗6个周期后分别行胃镜检查,在同一部位取胃组织,测定胃组织匀浆中CEA的表达.取10例肿瘤患者正常胃黏膜组织作为对照组.分别比较对照组和癌前病变组、癌前病变组治疗前后胃组织匀浆中CEA的表达.结果 癌前病变组、对照组胃组织匀浆中CEA分别为(27.76±9.67)、(3.32±0.60)μg/L,两组比较差异有统计学意义(P<0.05).癌前病变组治疗前后胃组织匀浆中CEA分别为(27.76±9.67)、(26.60±10.80)μg/L,两者比较差异有统计学意义(P<0.05).轻中度不典型增生、轻中度肠上皮化生胃组织匀浆中治疗前CEA分别为(23.11±4.11)、(17.10±1.66)μg/L,治疗后CEA分别为(21.11±5.66)、(15.10±3.31)μg/L,轻中度癌前病变治疗前后比较差异有统计学意义(P<0.05),重度癌前病变治疗前后比较差异无统计学意义.结论 化疗药物可明显降低轻中度癌前病变胃组织匀浆中CEA的表达,提示轻中度癌前病变有逆转可能.

Effect of chemotherapy drugs on the expression of carcinoembryonic antigen in the gastric tissue with gastric precancerous lesions in ectopic cancer

Objective To investigate the effect of chemotherapy drugs on the expression of carci-noembryonic antigen (CEA) in the gastric tissue with precancerous lesions in ectopie cancer. Methods There were 45 cases of cancer patients (precancerous lesions group), the pathological biopsy showed that there were atypical hyperplasia or intestinal metaplasia by gastroscope before chemotherapy. Gastruscope was done before chemotherapy and after six cycles of chemotherapy. Gastric tissue was taken respectively in the same site. The expression of CEA was measured in the gastric tissue. Normal gastric tissue taken from 10 cases of cancer patients was served as control. Compared respectively the expression of CEA in the gastric tissue in control group and precancerous lesions group, in precancerous lesions group between before and after treatment. Results CEA expression in the gastric tissue was (27.76±9.67), (3.32±0.60)μg/L in precancerous lesions group and control group respectively, there was significant difference between two groups(P<0.05). CEA expression in the gastric tissue was (27.76±9.67), (26.60±10.80)μg/L before and after treatment in precancerous lesions group respectively, P<0.05. CEA expression in the gastric tissue before treatment was (23.11±4.11), (17.10±1.66)μg/L, after treatment was (21.11±5.66), (15.10±3.31)μg/L in the mild to moderate atypical hyperplasia, mild to moderate intestinal metaplasia respectively, there was significant difference between before and after treatment in the mild to moderate precancerous lesions. There was no significant difference between before and after treatment in the severe precancerous lesions. Conclusions Chemotherapy drugs can significantly reduce the expression of CEA in the gastric tis-sue in the mild to moderate precancerous lesions. The results suggests that mild to moderate precancerous lesions can be reversed.