丹酚酸B/三七总皂苷配伍对心肌梗死大鼠左室结构和功能的影响*

[目的]研究丹酚酸B(Sal B)、三七总皂苷(PNS)对心肌梗死大鼠左室结构和功能的影响,探讨中药组分配伍的作用.[方法]结扎冠脉左前降支复制大鼠心肌梗死模型,假手术组作对照,连续灌胃给药7 d.用彩色超声心动仪观察心脏左室结构和功能变化.[结果]Sal B、PNS以及配伍组可以不同程度地降低左室收缩末期内径(LVDs)、左室收缩末期容积(LVESV),升高左室射血分数(EF)、左室短轴缩短率(FS),配伍组有优于其他中药组的趋势.[结论]Sal B、PNS配伍可以有效改善心肌梗死大鼠的左室结构和功能.

Effect of the combination of Sal B and PNS on left ventricular construction and function of rats with myocardial infarction

[Objective] In order to elucidate the scientific connotation of compatibility in traditional Chinese medicine (TCM) formulas,we observed the effects of Salvianolic acid B (Sal B) and panax notoginseng saponins (PNS) used alone and in combination on rats with acute myocardial infarction.[Methods] To produce myocardial infarction in anaesthetized rats by occluding the left descending coronary artery.Sham-operated rats served as controls.To assayed the construction and function of left ventricular by using echocardiography.[Results] Sal B,PNS and the combination of Sal B and PNS can decrease LVDs,LVESV and increase EF and FS. There was a trend that the effects of the combination of Sal B and PNS were better than others.[Conclusion] The combination of Sal B and PNS can improve the heart function effectively.