反流性食管炎治疗的生存质量和成本-效果分析

目的：评价埃索美拉唑治疗反流性食管炎（RE）的不同方案对患者生存质量的改善，并作成本-效果分析。方法：RE患者61例随机分成2组。A组：埃索美拉唑40mg qd 8周；B组：先予埃索美拉唑40mg qd，2周再予埃索美拉唑20mg qd 6周。2组同时联用莫沙比利5mg tid，8周。结果：A组与B组的症状有效率和内镜有效率差别均无统计学意义（P〉0.05）。SF-36量表评分2组都有5个维度积分较治疗前提高。B组的成本-效果比更佳。结论：对于RE患者，先予埃索美拉唑40mg每日1次2周，再予埃索美拉唑20mg每日1次6周与莫沙比利联合可能为更经济有效的选择。

Quality of Life and cost-effectiveness of Different Therapy for Reflux Esophagitis

Objective:To evaluate quality of life(QOL) and cost-effectivness of different plan of esomeprazole for reflux esophagitis(RE). Method:61 RE patients were randomized to 2 groups. Group A:esomeprazole 40mg once daily for 8 weeks; Group B:esomeprazole 40mg once daily for 2 weeks and then esomeprazole 20mg once daily for 6 weeks. All patients took mosapride 5mg three times daily for 8 weeks. Result:There was no statistic difference between group A and B in symptomatic effective rate and endoscopic effective rate. The scores of BP, GH, VT, SF and MH scales had significant improvement in group A and B after treatment. Group B was more cost effective. Conclusion: Esomeprazole 40mg once daily for 2 weeks and then esomeprazole 20mg once daily for 6 weeks puls mosapride perhaps the more cost effective therapy for RE patients.