Change in Corneal Permeability to Timolol After Laser In Situ Keratomileusis and Photorefractive Keratectomy in Rabbit |
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| Authors: | Naoki Hamada Shiro Amano Satoru Yamagami Makoto Araie Tetsuro Oshika Takahiro Wada Hiroko Miyai Yoshitada Notsu |
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| Affiliation: | (1) Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan;(2) Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan;(3) Sagami Research Laboratories, Wakamoto Pharmaceutical Company, Ltd., Kanagawa, Japan;(4) Department of Ophthalmology, University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan |
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| Abstract: | Purpose To evaluate the change in corneal permeability to timolol 1 month after laser in situ keratomileusis (LASIK) or photorefractive keratectomy (PRK) in rabbits.Methods LASIK or PRK was performed on one eye of each of 20 rabbits. One month later, 20 µl of 0.5% timolol was instilled into the 10 LASIK eyes, 10 PRK eyes, and the 20 control contralateral eyes. One hour later, 150µl of aqueous humor was collected from all eyes, and the concentration of timolol in the aqueous humor was measured by high-performance liquid chromatography. The effect of LASIK and PRK on the corneal permeability to timolol was analyzed.Results The average timolol concentrations in the aqueous humor of the ten eyes 1 month after LASIK and in the ten contralateral eyes were 1.16 ± 0.58µg/ml and 1.07 ± 0.39µg/ml (average ± SD, P = 0.678), respectively. The average timolol concentrations in the aqueous humor of the ten eyes 1 month after PRK and in the ten contralateral eyes were 1.24 ± 0.43µg/ml and 1.12 ± 0.30µg/ml (P = 0.483), respectively. The average ratio of timolol concentration in the aqueous humor of the LASIK or PRK eyes 1 month after surgery to that of the contralateral normal eyes was 1.18 ± 0.58 or 1.19 ± 0.67 (P = 0.972), respectively.Conclusions LASIK and PRK do not affect corneal permeability to timolol 1 month after surgery. Jpn J Ophthalmol 2005;49:12–14 © Japanese Ophthalmological Society 2005 |
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| Keywords: | corneal permeability laser in situ keratomileusis photorefractive keratectomy rabbit timolol |
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