2型糖尿病患者体脂状况与糖尿病性神经病变的关系

目的：观察2型糖尿病患者体脂状况对心自主神经病变和末梢神经病变的影响.方法：133例2型糖尿病患者（平均年龄58.7岁,平均病程13.1年,平均HbA1c 10.4%）根据WHO体重指数（BMI）标准分为5组（各组年龄、病程、HbA1c无显著性差异）.利用心自主神经功能检测系统和神经电生理检测仪测定心自主神经功能和肢体末梢神经传导速度、皮肤痛温觉、振动觉,诊断心自主神经和末梢神经病变.结果：各组间心自主神经病变和末梢神经病变的患病率无明显差异（P＞0.05）,各项神经功能检测指标无显著性差异.Logistic回归分析显示BMI与心自主神经病变和末梢神经病变无显著相关性.结论：2型糖尿病患者体脂状况对糖尿病性心自主神经病变和末梢神经病变无显著影响.

Relationship between body mass index and diabetic cardiovascular automonic neuropathy, peripheral polyneuropathy in patients with type 2 diabetes mellitus

Objective: To evaluate the relationship of BMI with diabetic cardiovascular autonomic neuropathy (CADN) and peripheral polyneuropathy (PNP) in patients with type 2 diabetes mellitus. Methods: 133 patients with type 2 diabetes mellitus ( mean age 58.7 years, mean duration 13.1 years, mean HbA_1c 10.4%) were divided into 5 groups according to WHO obesity criteria by BMI determination. Tests assessing cardiovascular autonomic functions coefficient of variation (CV),power spectrum in the low-frequency and high-frequency bands at rest,mean circular resultant (MCR) of vector analysis during deep breathing,the 30:15 ratio to standing,Valsalva ratio and postural change in systolic blood pressure] and peripheral nerve functions (motor and sensory nerve conduction velocities in the median, malleolar vibration perception threshold, and thermal perception thresholds) for diagnosis of CADN and PNP were performed using computer-based technique. Results: There was not significant difference of the prevalence of CADN and PNP between groups. No significant differences of parameters assessing nerve functions were shown between the studied groups. Logistic regression analysis showed no significant correlation between BMI and CADN,PNP. Conclusion: BMI doesn't affect diabetic cardiovascular autonomic neuropathy and peripheral neuropathy in patients with type 2 diabetes.