骨髓增生异常综合征患者外周血淋巴细胞微核观察

观察25例骨髓增生异常综合征(MDS)和30例正常人外周血淋巴细胞微核。MDS患者外周血微核淋巴细胞出现率为84.00%,淋巴细胞微核率为6.68‰,显著高于对照组(P<0.005)。RAEB和RAEB-T亚型淋巴细胞微核率显著高于RA亚型(P<0.005)。MDS微核淋巴细胞多微核率与对照组差异无显著性(P>0.05)。同时检查外周血淋巴细胞染色体,MDS染色体畸变率为14.68%,显著高于对照组,且与微核率呈直线正相关(r=0.76,P0.001)。本文就MDS微核检测的意义进行了讨论。

Study of micronuclem of lymphocytes in peripheral blood of myelodysplastic syndrome patients

The micronuclei of lymphocytes in peripheral blood were observed in 25 pati-ents wi th myelodyplastic syndrom (MDS) and 30 normal controls. The micronucleuslymphocyte frequency and micronucleus frequency of lymphocytes in MDS were84.00% and 6.68% respectively, significantly higher than those in the controls(P<0. 005). And the micronuclei frequencies of lymphocytes were much higherin RAEB and RAEB -T than in RA (P<0.005). There was no difference in mul-tiple micronucleus frequency of micronucleus lymphocytes between MDS and the controls (P>0.05) At the same time, the chromosomes of the lymphocytes inthe peripheral blood were examined and the chromosome abbration frequency inMDS was 14.68%,which was obviously higher than that in the controls and appear-ed linear positive correlation with micronucleus frequency (r=0. 76, P<0.001).The significance of micronucleus examination in MDS is discussed in this paper.