Adenosine and memory storage: |
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Authors: | Silvia R Kopf Alessia Melani Felicita Pedata G Pepeu |
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Institution: | Pharmakologisches Institut, Universit?t Mainz, Obere Zahlbacher Strasse 67, D-5501 Mainz, Deutschland, DE Department of Pharmacology, University of Florence, Viale Pieraccini 6, I-50139 Florence, Italy e-mail: pepeu@server1.pharm.unifi.it Fax: +39-055-4271-280, IT
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Abstract: | Rationale: Caffeine is a non-selective A1/A2 adenosine receptor antagonist which is known to improve cognitive performance in humans. This effect of caffeine has been
attributed to its antagonism of adenosine receptors. Objective: The present study was devised to identify the role of A1 and A2A adenosine receptors in the facilitation of memory consolidation in mice performing a passive avoidance task. Methods: Adult albino Swiss male mice were used. The mice were trained in a step-through inhibitory avoidance task in which they were
punished by a foot-shock (0.4 mA, 5 Hz, for 3 s) delivered through the grid floor. Caffeine (0.1, 0.3, 1.0 and 3.0 mg/kg),
SCH 58261 (0.1, 0.3, 1.0 and 3.0 mg/kg) and DPCPX (0.1, 0.3, 1.0 and 3.0 mg/kg) were injected IP immediately or 180 min after
training. The retention test was performed 24 h after training. Results: Caffeine and the selective A2A adenosine receptor antagonist SCH 58261 facilitated retention when administered immediately after training, but not when
administered 180 min later. The dose response was a bell-shaped curve. Conversely, post-training administration of the selective
A1 adenosine receptor antagonist DPCPX did not affect retention. Caffeine and SCH 58261 had no effect in mice not given the foot-shock
on the training trial, a finding indicating that the drug’s effect on retention was specific. Conclusions: These results suggest that A2A but not A1 adenosine receptors are involved in memory retention and consolidation.
Received: 14 February 1999 / Final version: 23 April 1999 |
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Keywords: | Adenosine Memory Passive avoidance Caffeine DPCPX SCH 58261 |
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